Efficacy of bronchoscopic suction combined with bronchoalveolar lavage on severe pneumonia complicated with respiratory failure and its influence on CPIS score and serum inflammatory markers
Objective To explore the efficacy of bronchoscopic suction combined with bronchoalveolar lavage on severe pneumonia complicated with respiratory failure and its influence on clinical pulmonary infection score(CPIS)and serum inflammatory markers.Methods 66 patients with severe pneumonia complicated with respiratory failure were divided into a control group and an observation group according to the difference of treatment plan,with 33 cases in each group.The control group was treated with bronchoalveolar lavage,and the observation group was treated with bronchoscopic suction combined with bronchoalveolar lavage.The CPIS score,blood gas index,serum inflammatory markers and lung function before and after treatment,and therapeutic effect were compared between the two groups.Results After treatment,the scores of body temperature,white blood cell count,tracheal secretions,oxygenation,chest X-ray,progression of lung infiltration and tracheal aspirate culture in both groups were significantly lower than those before treatment in this group;the scores of body temperature,white blood cell count,tracheal secretions,oxygenation,chest X-ray,progression of lung infiltration and tracheal aspirate culture in the observation group were lower than those in the control group(P<0.05).After treatment,the arterial partial pressure of carbon dioxide in both groups was significantly lower than that before treatment in this group,and the arterial oxygen saturation and arterial partial pressure of oxygen were higher than those before treatment in this group;the arterial partial pressure of carbon dioxide in the observation group was significantly lower than that in the control group,and the arterial oxygen saturation and arterial partial pressure of oxygen in the observation group were higher than those in the control group(P<0.05).After treatment,the serum levels of interleukin-6,tumor necrosis factor-α and hypersensitive C-reactive protein in both groups were lower than those before treatment in this group;the observation group had serum interleukin-6 of(15.85±2.72)ng/L,tumor necrosis factor-α of(63.76±5.61)ng/L,and hypersensitive C-reactive protein of(32.86±3.93)mg/L,which were lower than(22.73±3.31)ng/L,(85.59±7.23)ng/L,and(50.25±6.70)mg/L in the control group(P<0.05).After treatment,the forced expiratory volume in one second,peak expiratory flow and forced vital capacity in both groups were higher than those before treatment in this group;the forced expiratory volume in one second in the observation group was(1.82±0.24)L,the peak expiratory flow was(3.37±0.28)L/s and the forced vital capacity was(1.98±0.35)L,which were higher than(1.45±0.26)L,(2.84±0.21)L/s and(1.58±0.29)L in the control group(P<0.05).The total effective rate of 90.91%in the observation group was significantly higher than 63.64%in the control group(P<0.05).Conclusion Bronchoscopic suction combined with bronchoalveolar lavage can improve the therapeutic effect of patients with severe pneumonia complicated with respiratory failure,reduce the CPIS score and serum inflammatory markers of patients,and help to restore normal lung function as soon as possible.
万方数据
维普
