The efficacy and safety evaluation of aspirin combined with Femoston in the repair of endometrium after severe intrauterine adhesion surgery
Objective To evaluate the efficacy and safety evaluation of aspirin combined with complex packing estradiol tablets/estradiol and dydrogesterone tablets(trade name:Femoston)in the repair of endometrium after severe intrauterine adhesion surgery.Methods 60 patients with severe intrauterine adhesions were divided into a control group and a treatment group by drawing lots,with 30 cases in each group.The control group was treated with Femoston,and the treatment group was treated with aspirin and Femoston.Both groups were compared in terms of clinical efficacy,menstrual recovery effect,occurrence of adverse reactions and menstrual blood volume,endometrial thickness,uterine artery blood flow parameters[flow index(FI),vascularized flow index(VFI),vascularization index(VI),pulsatility index(PI),resistance index(RI)],and quality of life before and after the treatment.Results Compared with the control group,the total clinical effective rate of the treatment group was higher,but the difference was not statistically significant(P>0.05).Compared with the control group,the total effective rate of menstrual recovery in the treatment group was higher,but the difference was not statistically significant(P>0.05).After treatment,the treatment group had more menstrual blood volume of(57.10±4.45)ml than(46.13±4.40)ml in the control group,and greater endometrial thickness of(9.79±1.36)mm than(8.26±1.18)mm in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the treatment group had FI of(28.20±1.70),VFI of(1.23±0.11)and VI of(4.39±0.45)%,which were significantly higher than(23.53±3.70),(0.90±0.08)and(3.23±0.36)%in the control group;the treatment group had PI of(1.28±0.15)and RI of(1.03±0.10),which were significantly lower than(1.86±0.25)and(1.24±0.15)in the control group(P<0.05).After treatment,the scores of material life status,psychological function,physical function and social function in the treatment group were(82.75±10.24),(81.32±10.32),(82.48±11.10)and(83.10±12.35)points,which were significantly higher than(74.16±11.18),(75.68±10.28),(73.78±11.28)and(73.57±12.20)points in the control group(P<0.05).Conclusion The combined treatment of aspirin and Femoston for patients after severe intrauterine adhesions surgery has high effectiveness and safety,which is beneficial for endometrial repair,menstrual recovery,and improvement of quality of life.It is worth promoting.
Severe intrauterine adhesionAspirinComplex packing estradiol tablets/estradiol and dydrogesterone tabletsEndometrial repairSafety
万方数据
维普
