Observation on the therapeutic effect of clopidogrel hydrogen sulphate tablets combined with butylphthalein soft capsules on cerebral infarction and its influence on serum specific indicators
Objective To explore the therapeutic effect of clopidogrel hydrogen sulphate tablets combined with butylphthalein soft capsules on cerebral infarction and its influence on serum specific indicators,so as to enrich clinical theoretical basis.Methods 80 patients with cerebral infarction were randomly divided into a control group(40 cases)and an observation group(40 cases).The control group was treated with clopidogrel hydrogen sulphate tablets,and the observation group was treated with clopidogrel hydrogen sulphate tablets combined with butylphthalein soft capsules.Both groups were compared in terms of serum specific indicators(serum S100-β protein,CD40L),cerebral circulation blood volume parameters(average cerebral blood flow velocity,peripheral vascular resistance,vascular characteristic impedance),neurotrophin[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)]levels,quality of life[stroke specific quality of life scale(SS-QOL)score]and clinical effect.Results The total effective rate of the observation group was 90.00%,which was higher than 72.50%of the control group(P<0.05).After treatment,the serum levels of S100-β protein and CD40L in both groups were lower than those before treatment in this group;the observation group had serum S100-β protein of(0.23±0.05)ng/ml and CD40L of(9.69±1.34)μg/L,which were lower than(0.41±0.12)ng/ml and(11.57±2.01)μg/L in the control group(P<0.05).After treatment,the average cerebral blood flow velocity in both groups was higher than that before treatment in this group,and the peripheral vascular resistance,vascular characteristic impedance were lower than those before treatmentin this group;the observation group had higher average cerebral blood flow velocity of(11.60±5.22)cm/s than(8.89±4.73)cm/s in the control group;the observation group had the peripheral vascular resistance of(2367.31±129.16)BSA and vascular characteristic impedance of(3017.83±136.95)dyn·s/cm5,which were lower than(2861.42±137.20)BSA and(4089.35±160.74)dyn·s/cm5 in the control group(P<0.05).After treatment,the levels of serum BDNF and NGF in both groups were higher than those before treatment in this group;the observation group had serum BDNF of(4.35±0.83)ng/ml and NGF of(138.36±18.92)pg/ml,which were higher than(3.17±0.72)ng/ml and(126.53±19.09)pg/ml in the control group(P<0.05).After treatment,the SS-QOL scores of physical fitness,mobility,self-care,social role,upper limb function and working ability of the two groups were higher than those before treatment;the SS-QOL scores of physical fitness,activity ability,self-care,social role,upper limb function and work ability in the observation group were higher than those in the control group(P<0.05).Conclusion Clopidogrel hydrogen sulphate tablets combined with butylphthalein soft capsules can be used as an effective treatment for cerebral infarction,which can improve the serum specific indicators,improve the level of neuronutrition,promote brain blood circulation,and contribute to early recovery of patients.
万方数据
维普
