Effect analysis of alprazolam combined with trimebutine maleate on inflammation,immune function and prognosis of functional gastrointestinal disease patients
Objective To analyze the effect of alprazolam combined with trimebutine maleate on functional gastrointestinal disease,and its influence on inflammation,immune function and prognosis of patients.Methods 88 patients with functional gastrointestinal disease were divided into a control group and a study group according to random number table method,with 44 cases in each group.The control group was treated with trimebutine maleate,and the study group was treated with alprazolam combined with trimebutine maleate.Comparison was made on clinical efficacy,inflammatory factors[interleukin-12(IL-12),interleukin-10(IL-10),interleukin-8(IL-8)],immune function(CD3+,CD4+,CD8+,CD4+/CD8+)and Pittsburgh Sleep Quality Index(PSQI)scores between the two groups.Results The total effective rate of the study group was 97.73%,which was higher than the control group's 81.82%(P<0.05).Before treatment,there were no differences in IL-12,IL-10 and IL-8 levels between the two groups(P>0.05).After treatment,the levels of IL-12 and IL-8 in the study group were lower than those in the control group,and the level of IL-10 was higher than that in the control group(P<0.05).Before treatment,there was no differences in CD3+,CD4+,CD8+and CD4+/CD8+between the two groups(P>0.05).After treatment,the study group had lower CD8+of(29.43±5.26)%than(34.67±5.09)%in the control group;the study group had CD3+of(80.49±5.62)%,CD4+of(49.88±5.71)%and CD4+/CD8+of(1.92±0.37),which were higher than(73.49±7.51)%,(43.29±4.82)%and(1.61±0.25)in the control group(P<0.05).Before treatment,there was no differences in PSQI scores between the two groups(P>0.05).After treatment,the study group had lower PSQI score of(11.06±1.37)points than(15.12±1.45)points in the control group(P<0.05).Conclusion The combination of alprazolam and trimebutine maleate in the treatment of functional gastrointestinal disease has a good effect,which can effectively improve the inflammation and immune function of patients,and is worthy of clinical promotion.
AlprazolamTrimebutine maleateFunctional gastrointestinal diseaseInflammationImmune function
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维普
