Mechanism of Chinese Yam in the treatment of dyspeptic diarrhea in children based on network pharmacology and molecular docking
Objective To explore the potential mechanism of Chinese Yam in the treatment of dyspeptic diarrhea in children based on network pharmacology and molecular docking.Methods The active constituents and associated targets of Chinese Yam were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).The Genecards database was employed to conduct a screening of disease-associated targets for dyspeptic diarrhea in children.The Venn diagram was utilized to establish the shared target between Chinese Yam and dyspeptic diarrhea in children,employing the JVenn tool.The protein-protein interaction network,drug-active ingredient-target gene network,gene ontology functional analysis(GO),and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were conducted using the STRING,Cytoscape,and INPUT platforms,respectively.The molecular docking verification was performed using the EzCad online molecular docking platform.Results The Chinese Yam was found to contain a total of 19 active compounds.In the context of dyspeptic diarrhea in children,a comprehensive analysis identified 152 potential targets.Notably,there were 42 targets that were commonly shared between the active ingredients in Chinese Yam and the prospective targets associated with dyspeptic diarrhea in children.Interleukin-6(IL-6),tumor necrosis factor(TNF),prostaglandin-endoperoxide synthase 2(PTGS2),estrogen receptor alpha(ESR1),chemokine ligand 2(CCL2),and nuclear factor kappa B subunit 1(NF-κB1)represent prospective protein targets for the implementation of Chinese Yam-based interventions in pediatric patients suffering from dyspeptic diarrhea.The therapeutic effects of Chinese Yam treatment in pediatric patients with dyspeptic diarrhea may be intricately linked to various signaling pathways,including the 5-hydroxytryptaminergic synapse,calcium ion signaling system,viral illnesses,hypoxia-inducible factor(HIF-1)signaling pathway,and inflammatory bowel disease.Conclusion The active constituents found in Chinese Yam exhibit the ability to interfere with various potential targets by engaging multiple signaling pathways.This characteristic aligns with the principles of Chinese traditional medicine,which emphasizes the use of multiple components,pathways,and targets.These findings offer valuable insights into the mechanism by which Chinese Yam may be effective in treating dyspeptic diarrhea in children,warranting further investigation.
Chinese YamDyspeptic diarrhea in childrenNetwork pharmacologyMolecular docking
万方数据
维普
