Clinical study on the effect of Shexiang Baoxin Pill mediated changes of endothelial function on short-term prognosis of patients with heart failure after myocardial infarction
Objective To analyze the effect of Shexiang Baoxin Pill mediated changes of endothelial function on short-term prognosis of patients with heart failure after myocardial infarction.Methods 43 patients with heart failure after myocardial infarction were included in the study,and were randomly divided into a control group(21 cases)and an observation group(22 cases).Patients in both groups received conventional Western drugs for secondary prevention of coronary heart disease and heart failure,and patients in the observation group were treated with Shexiang Baoxin pill on the basis of conventional Western medicine treatment.Both groups were compared in terms of cardiac function[heart rate(HR),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)],routine blood parameters[prothrombin time(PT),plasma fibrinogen(FIB),platelet aggregation test(PAgT)],flow cytometry indicators[helper T lymphocyte 1(Th1),helper T lymphocyte 17(Th17)and regulatory T cells(Treg)],inflammatory factors[interleukin-10(IL-10),interleukin-6(IL-6),C-reactive protein(CRP)].Results After 1 year of treatment,the observation group had higher LVEF of(59.12±3.83)%than(55.88±3.97)%in the control group;the observation group had HR of(76.14±6.69)beats/min and LVEDD of(54.47±2.91)mm,which were lower than(80.61±5.92)beats/min and(57.63±2.16)mm in the control group;the statistical significance was established(P<0.05).After 1 year of treatment,the observation group had longer PT of(13.93±2.01)s than(12.63±2.07)s in the control group;the observation group had FIB of(4.02±0.98)g/L and PAgT of(59.63±7.31)%,which were lower than(4.79±1.02)g/L and(67.56±6.91)%in the control group;the statistical significance was established(P<0.05).After 1 year of treatment,Th1 and Th17 in the observation group were lower than those in the control group,and Treg was higher than that in the control group.The statistical significance was established(P<0.05).After 1 year of treatment,the observation group had IL-10 of(36.67±6.38)pg/ml,IL-6 of(130.63±24.36)pg/ml and CRP of(33.12±8.93)mg/L,which were lower than(43.08±7.11)pg/ml,(169.67±29.61)pg/ml and(49.68±10.47)mg/L in the control group.The statistical significance was established(P<0.05).Conclusion Shexiang Baoxin Pill mediated changes of endothelial function can significantly improve the cardiac function level of patients with heart failure after myocardial infarction,enhance the immune function,and reduce the level of inflammatory factors.The comprehensive application value of Shexiang Baoxin pill is high,and it is recommended to be promoted in clinical use.
Shexiang Baoxin PillEndothelial functionHeart failure after myocardial infarctionShort-term prognosis
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