Study on effect of budesonide combined with azithromycin in the treatment of bronchial asthma
Objective To explore the effect of budesonide combined with azithromycin in the treatment of bronchial asthma.Methods 110 patients with bronchial asthma were randomly divided into a study group and a control group,with 55 cases in each group.The control group was treated with azithromycin,and the study group was treated with budesonide combined with azithromycin.Comparison was made on symptom improvement time,therapeutic effect,pulmonary function and inflammatory indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),C-reactive protein],adverse events and quality of life between the two groups.Results The improvement time of asthma,dyspnea,pulmonary murmur and cough in the study group were(3.37±1.26),(2.04±0.21),(5.02±0.44)and(4.03±0.57)d,which were shorter than(6.37±2.12),(3.56±1.22),(8.17±1.26)and(5.21±0.43)d in the control group,and the comparison showed that there was statistical value(P<0.05).The total effective rate of 96.36%in the study group was significantly higher than 78.18%in the control group,and the comparison showed that there was statistical value(P<0.05).The incidence of adverse events in the study group was lower than that in the control group,and the comparison showed that there was statistical value(P<0.05).The study group had FEV1 of(2.75±0.68)L and FVC of(3.65±0.84)L,which were significantly higher than(2.22±0.37)and(2.71±0.76)L in the control group;the study group had lower C-reactive protein of(2.66±0.56)mg/L than(5.07±0.88)mg/L in the control group;the comparison showed that there was statistical value(P<0.05).In the study group,the scores of physical pain,vital vitality,physiological function and emotional function were(83.57±7.21),(84.66±9.18),(85.36±9.07)and(83.21±9.54)points,which were higher than(76.44±8.34),(80.30±8.09),(80.49±8.36)and(75.64±8.56)points in the control group.The comparison showed that there was statistical value(P<0.05).Conclusion The combination of azithromycin and budesonide can effectively improve the pulmonary function and inflammatory indicators of patients with bronchial asthma,improve the therapeutic effect,prevent adverse events,thus improving the quality of life of patients.
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