Effect of oral administration of simethicone at different times before colonoscopy on intestinal cleanliness and diagnostic efficacy
Objective To explore the effect of oral administration of simethicone at different times before colonoscopy on intestinal cleanliness and diagnostic efficacy.Methods 135 patients undergoing colonoscopy were selected and divided into an observation group A(45 cases),an observation group B(45 cases)and an observation group C(45 cases)according to random number table method.In all three groups,polyethylene glycol-electrolyte powder was administered orally 6 h before colonoscopy,while 30 ml of simethicone was added 0.5,1 and 2 h before the examination in observation groups A,B and C,respectively.The three groups were compared in terms of Boston Bowel Preparedness Scale(BBPS)scores,bubble scores,colonoscopy lens clarity scores and amount of normal saline,detection rate of intestinal polyps and colorectal adenoma,and the occurrence of adverse reactions.Results Observation group B had BBPS score of(8.34±0.87)points,bubble score of(8.11±0.83)points,which were significantly higher than(7.80±0.69)and(7.61±0.65)points of observation group A,and(7.69±0.57)and(7.42±0.63)points of observation group C.The difference was statistically significant(P<0.05).Observation group A and observation group C had similar BBPS scores and bubble scores(P>0.05).Observation group B had colonoscopy lens clarity score of(0.71±0.18)points and amount of normal saline of(15.33±4.38)ml,which were obviously lower than(0.89±0.24)points and(21.57±5.81)ml in observation group A,and(0.93±0.27)points and(22.74±6.12)ml in observation group C.The difference was statistically significant(P<0.05).The colonoscopy lens clarity score and the amount of normal saline were similar between observation group A and observation group C(P>0.05).The detection rates of intestinal polyps>5 mm in diameter and colorectal adenomas were similar in the three groups(P>0.05).The detection rate of intestinal polyps≤5 mm in diameter was 31.11%in group B,which was significantly higher than that in group A(6.67%)and group C(8.89%),and the difference was statistically significant(P<0.05).The detection rate of intestinal polyps≤5 mm in diameter was similar between observation group A and observation group C(P>0.05).The incidence rates of adverse reactions in observation groups A,B,and C were 8.89%,11.11%,and 8.89%,and the difference was not statistically significant(P>0.05).Conclusion Oral administration of 30 ml of simethicone 1 h before colonoscopy can significantly improve intestinal cleanliness,colonoscopy lens clarity,detection of intestinal polyps≤5 mm in diameter,improve the bubble situation,and has high safety.
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