利拉鲁肽联合运动康复治疗对老年2型糖尿病合并脑卒中的疗效及对炎症水平的影响
The efficacy of liraglutide combined with exercise rehabilitation therapy on elderly patients with type 2 diabetes mellitus and stroke and its influence on the inflammation level
王咏梅1
作者信息
- 1. 253016 德州市中西医结合医院(德州市肛肠医院)普内科
- 折叠
摘要
目的 研讨利拉鲁肽联合运动康复治疗对老年 2 型糖尿病合并脑卒中的疗效及对炎症水平的影响.方法 80 例 2 型糖尿病合并脑卒中患者,以电脑随机数字表法分为对照组和观察组,每组 40 例.对照组采用运动康复治疗,观察组在对照组基础上展开利拉鲁肽治疗.比较两组患者治疗效果以及治疗前后的血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平.结果 观察组治疗总有效率 97.50%高于对照组的 75.00%(P<0.05).治疗前,观察组TNF-α、IL-6、CRP水平分别为(105.21±7.57)ng/L、(25.36±5.55)pg/ml、(18.16±2.47)mg/L;对照组TNF-α、IL-6、CRP水平分别为(105.66±7.44)ng/L、(25.81±5.71)pg/ml、(18.58±2.55)mg/L.治疗后,观察组TNF-α、IL-6、CRP水平分别为(46.09±3.47)ng/L、(6.05±1.27)pg/ml、(4.05±1.09)mg/L,对照组TNF-α、IL-6、CRP水平分别为(59.77±4.55)ng/L、(7.47±1.94)pg/ml、(5.39±1.25)mg/L.治疗前,两组IL-6、TNF-α、CRP水平差异较小(P>0.05);治疗后,两组IL-6、TNF-α、CRP水平均较治疗前降低,且观察组降低程度均优于对照组(P<0.05).结论 老年 2 型糖尿病合并脑卒中患者实施利拉鲁肽联合运动康复治疗,可确保疗效,改善患者机体炎症水平.
Abstract
Objective To explore the efficacy of liraglutide combined with exercise rehabilitation therapy on elderly patients with type 2 diabetes mellitus and stroke and its influence on the inflammation level.Methods 80 patients with type 2 diabetes mellitus and stroke were divided into a control group and an observation group by computer random number table method,with 40 cases in each group.The control group was treated with exercise rehabilitation,and the observation group was treated with liraglutide on the basis of the control group.The therapeutic effect and serum levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]before and after treatment were compared between the two groups.Results The observation group had higher total effective rate of 97.50%than 75.00%in the control group(P<0.05).Before treatment,the levels of TNF-α,IL-6 and CRP in the observation group were(105.21±7.57)ng/L,(25.36±5.55)pg/ml and(18.16±2.47)mg/L;the levels of TNF-α,IL-6 and CRP in the control group were(105.66±7.44)ng/L,(25.81±5.71)pg/ml and(18.58±2.55)mg/L.After treatment,the levels of TNF-α,IL-6 and CRP in the observation group were(46.09±3.47)ng/L,(6.05±1.27)pg/ml and(4.05±1.09)mg/L;the levels of TNF-α,IL-6 and CRP in the control group were(59.77±4.55)ng/L,(7.47±1.94)pg/ml and(5.39±1.25)mg/L.Before treatment,the levels of IL-6,TNF-α and CRP in the two groups had little difference(P>0.05).After treatment,the levels of IL-6,TNF-α and CRP in the two groups were decreased compared with those before treatment,and the reduction of the observation group was better than that of the control group(P<0.05).Conclusion In elderly patients with type 2 diabetes mellitus and stroke,the combination of liraglutide and exercise rehabilitation therapy can ensure the efficacy and improve the inflammatory level of patients.
关键词
2型糖尿病/脑卒中/运动康复/利拉鲁肽/疗效/炎症水平/生活质量/老年Key words
Type 2 diabetes mellitus/Stroke/Exercise rehabilitation/Liraglutide/Efficacy/Inflammation level/Quality of life/Old age引用本文复制引用
出版年
2024
NETL
NSTL
万方数据