Analysis of the effect of ivabradine in the treatment of tachyarrhythmia
Objective To explore the clinical efficacy of ivabradine in the treatment of tachyarrhythmia,so as to provide new ideas for the treatment effect of arrhythmia patients.Methods 90 patients with tachyarrhythmia were selected for the study,and they were divided into a control group(n=45,treated with metoprolol succinate)and an experimental group(n=45,treated with metoprolol succinate combined with ivabradine)according to different treatment methods.Comparison was made on treatment efficacy,heart rate variability indicators[adjacent NN interval difference 50 ms percentage(PNN50),root mean square of the successive normal sinus R-R interval difference(RMSSD),standard diviation average of NN intervals(SDANN),standard diviation of NN intervals(SDNN)],and arrhythmia indicators between the two groups.Results After treatment,the total effective rate of the experimental group was 97.78%,which was higher than 77.78%of the control group,and the difference between groups was significant(P<0.05).Before treatment,PNN50,RMSSD,SDANN and SDNN were similar between the two groups,and there was no significant difference between the two groups(P>0.05).After treatment,PNN50,RMSSD,SDANN and SDNN in the experimental group were(10.49±3.17)%,(28.80±5.16)ms,(116.18±32.81)ms and(122.63±28.40)ms,and those in the control group were(8.81±3.36)%,(26.35±4.41)ms,(99.13±25.76)ms and(108.27±20.29)ms.After treatment,PNN50,RMSSD,SDANN and SDNN were significantly improved in both groups,and the improvement amplitude of the experimental group was greater than that of the control group,the difference was significant(P<0.05).After treatment,the number of ventricular tachycardia episodes in the experimental group was(1621.25±265.55)times,which was lower than(2635.75±378.35)times in the control group,and the difference between groups was significant(t=14.723,P=0.000<0.05).The time required for arrhythmia recovery in the experimental group was(14.48±2.68)d,which was shorter than(18.37±2.87)d in the control group,and the difference between groups was significant(t=6.645,P=0.000<0.05).Conclusion Ivabradine has a significant therapeutic effect on tachyarrhythmia,which can effectively improve heart rate variability and arrhythmia indicators in patients,improve clinical treatment effectiveness,and have clinical promotion and application value.
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