Comparison of efficacy between high-dose dual therapy and classic quadruple therapy in eradicating Helicobacter pylori
Objective To explore and compare the clinical effect of high-dose dual therapy and classic quadruple therapy in eradicating Helicobacter pylori.Methods 76 cases of Helicobacter pylori positive patients were selected and randomly divided into an observation group and a control group by random numerical table,each with 38 cases.The control group was treated with classic quadruple therapy(amoxicillin+bismuth potassium citrate+esomeprazole+clarithromycin),while the observation group was treated with high-dose dual therapy(amoxicillin+esomeprazole).The eradication rate of Helicobacter pylori,adverse reaction rate,and the serum inflammatory factor[serum tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and interleukin-6(IL-6)]levels were compared between the two groups.Results The eradication rate of Helicobacter pylori in the control group was 89.47%(34/38),and that in the observation group was 94.74%(36/38).There was no significant difference in eradication rate of Helicobacter pylori between the two groups(χ2=0.724,P=0.395>0.05).Compared with 21.05%in the control group,the incidence of adverse reactions in the observation group was significantly lower(5.26%),and the difference was significant(P<0.05).Before treatment,there were no significant differences in IL-6,IL-8 and TNF-α between the two groups(P>0.05).After treatment,the levels of IL-6,IL-8 and TNF-α in both groups were lower than those before treatment;the observation group had IL-6 of(3.86±1.03)pg/ml,IL-8 of(0.06±0.05)pg/L and TNF-α of(138.62±26.31)ng/ml,which were lower than(4.69±1.05)pg/ml,(0.11±0.08)pg/L and(351.62±29.62)ng/ml in the control group(P<0.05).Conclusion The clinical effect of classical quadruple therapy and high-dose dual therapy in Helicobacter pylori eradication is comparable,but high-dose dual therapy can reduce adverse drug reactions,ensure the health and safety of patients,and is beneficial to improving the level of serum inflammatory factors in patients,which is worthy of promotion and application.
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