Clinical efficacy study of dexibuprofen suppositories on renal colic caused by ureteral calculus
Objective To explore the clinical efficacy and safety of dexibuprofen suppositories on renal colic caused by ureteral calculus.Methods 64 patients diagnosed with renal colic caused by ureteral calculus were divided into a control group and an observation group by random number method,with 32 cases in each group.Both groups were treated with anisodamine hydrobromide.On this basis,the control group was treated with diclofenac sodium suppository,and the observation group was treated with dexibuprofen suppositories.Patients in both groups were compared in terms of clinical efficacy,symptom relief time(time for pain relief,time for complete pain relief),serum inflammatory factors[serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)],and the occurrence of adverse reactions.Results The total effective rate was 96.88%in the control group and 90.63%in the observation group.There was no significant difference in the total clinical effective rate between the two groups(χ2=1.067,P=0.302>0.05).The time for pain relief in the control group was(18.73±3.12)min,and that in the observation group was(12.67±2.91)min;there was a statistically significant difference between the two groups(t=8.035,P=0.000<0.05).The time for complete pain relief in the control group was(34.12±3.04)min,and that in the observation group was(24.62±4.81)min;there was a statistically significant difference between the two groups(t=9.444,P=0.000<0.05).Compared with before treatment,the serum levels of IL-6,TNF-α and IL-1β in both groups were significantly decreased after treatment(P<0.05).After treatment,the observation group had serum IL-6 of(4.10±0.15)pg/ml,TNF-α of(16.25±3.17)pg/ml and IL-1β of(2.11±0.17)pg/ml,which were significantly decreased compared with(4.67±0.37),(20.01±2.01)and(2.86±0.15)pg/ml in the control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(χ2=0,P=1>0.05).Conclusion For patients with renal colic caused by ureteric calculus,the application of dexibuprofen suppositories is better than diclofenac sodium suppositories in improving the pain symptoms and reducing the inflammatory response of the body,and the safety is controllable,which is worthy of clinical promotion.
NETL
NSTL
万方数据
