Analysis of the therapeutic effect of naloxone in the treatment of COPD with respiratory failure and pulmonary encephalopathy
Objective To explore the practical effect of naloxone in the treatment of chronic obstructive pulmonary disease(COPD)with respiratory failure and pulmonary encephalopathy.Methods 78 COPD patients with respiratory failure and pulmonary encephalopathy were selected and randomly divided into a control group[n=39,treated with bi-level positive airway pressure ventilation(BiPAP)non-invasive positive pressure ventilation via nasal mask]and a study group(n=39,treated with naloxone in addition to the control group)using a random number table method.Both groups were compared in terms of treatment effect,blood gas indicators[blood oxygen saturation(SpO2),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)],lung function indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC],clinical indicators(respiratory failure correction time,infection control window appearance time,ventilator use time,tracheal intubation rate and hospital stay),and inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)].Results The total effective rate of the study group was 94.87%,which was higher than 74.36%of the control group(P<0.05).After treatment,the study group had SpO2 of(98.36±6.01)%and PaO2 of(70.63±4.51)mm Hg(1 mm Hg=0.133 kPa),which were higher than(94.31±5.28)%and(61.21±4.23)mm Hg in the control group;the study group had lower PaCO2 of(46.24±2.42)mm Hg than(54.02±2.63)mm Hg in the control group(P<0.05).After treatment,the study group had FEV1 of(3.21±0.57)L,FVC of(3.59±0.24)L and FEV1/FVC of(74.36±5.34)%,which were higher than(2.34±0.63)L,(3.05±0.43)L and(68.24±4.12)%in the control group(P<0.05).In the study group,the respiratory failure correction time,infection control window appearance time,ventilator use time,and hospital stay were(1.53±0.37),(4.76±0.54),(6.31±0.65)and(9.34±1.03)d,which were shorter than(2.54±0.65),(6.55±0.84),(8.81±1.05)and(14.52±1.13)d in the control group;the study group had lower tracheal intubation rate of 5.13%than 23.08%in the control group(P<0.05).After treatment,the study group had IL-6 of(20.14±2.06)ng/L,CRP of(6.65±0.71)mg/L,and PCT of(1.31±0.26)ng/ml,which were lower than(23.04±2.13)ng/L,(8.23±0.87)mg/L,and(1.62±0.34)ng/ml in the control group(P<0.05).Conclusion The use of naloxone in the treatment of COPD with respiratory failure and pulmonary encephalopathy can reduce the body's inflammatory response,improve the patient's blood gas indicators and lung function,effectively alleviate clinical symptoms,reduce tracheal intubation rate,and promote the improvement of the patient's condition.
Chronic obstructive pulmonary diseaseRespiratory failurePulmonary encephalopathyNaloxoneBlood gas indicatorsTreatment effect
NETL
NSTL
万方数据
