comparison of the impact of raloxifene and clomiphene on serum sex hormone levels and ovulation status of patients with polycystic ovary syndrome and infertility
Objective To explore the impact of raloxifene and clomiphene on serum sex hormone levels and ovulation status of patients with polycystic ovary syndrome(PCOS)and infertility.Methods A total of 100 patients with PCOS and infertility were selected for analysis.They were divided into a control group and a study group by computer table method,,with 50 patients in each group.The control group was treated with clomiphene,and the study group was treated with raloxifene.Patients in both groups were compared in terms of serum sex hormones[progesterone(P),estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T)]levels,follicular and endometrial conditions[endometrial thickness,endometrial spiral artery pulsatility index(PI),resistance index(RI)],treatment effects,and adverse reactions.Results After treatment,the study group had higher serum LH level of(9.74±1.36)IU/L than(8.42±1.19)IU/L in the control group,and lower T level of(1.59±0.48)nmol/L than(2.64±0.65)nmol/L in the control group.The difference was statistically significant(P<0.05).The study group had higher number of mature follicles of(1.41±0.28)than(1.12±0.24)in the control group,and shorter time of follicle maturation of(12.85±1.44)d than(14.96±1.14)d in the control group.The difference was statistically significant(P<0.05).The study group had higher endometrial thickness of(9.45±1.25)mm than(6.45±1.17)mm in the control group;the study group had endometrial spiral artery PI of(1.24±0.11)and RI of(0.61±0.09),which were lower than(1.41±0.25)and(0.86±0.07)in the control group;the difference was statistically significant(P<0.05).The total effective rate of the study group was 96.00%,which was higher than 92.00%in the control group,but the difference was not statistically significant(P>0.05).The incidence of adverse reactions in the study group was 2.00%,which was lower than 14.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with clomiphene,raloxifene has a significant effect on the treatment of PCOS with infertility.It can improve serum sex hormone levels,reduce adverse reactions,and improve the condition of the endometrium in patients.It is worthy of widespread use.
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