Analysis of the clinical efficacy,safety of prone position ventilation in the treatment of children with pneumonia and respiratory failure and its influence on dynamic pulmonary compliance
Objective To analyze the clinical efficacy,safety of prone position ventilation in the treatment of children with pneumonia and respiratory failure and its influence on pulmonary dynamic compliance(Cdyn).Methods 90 children with pneumonia and respiratory failure were divided into a study group and a control group,according to different treatment methods was with 45 cases in each group.The control group was treated with supine position ventilation,and the study group treated with prone position ventilation.Patients in both groups were compared in terms of total duration of mechanical ventilation,the length of pediatric intensive care unit(PICU)stay,the occurrence of adverse events,pulmonary function[minute ventilation volume(MVV),tidal volume(VT)and dynamic pulmonary compliance],blood gas parameters[arterial partial pressure of oxygen(PaO2)and blood oxygen saturation(SaO2)]before and after treatment.Results In the study group,the total duration of mechanical ventilation was(70.28±7.67)h and the length of PICU stay was(5.12±0.49)d,which were significantly shorter than(93.35±9.32)h and(7.57±0.57)d in the control group,and the difference was statistically significant(P<0.05).After treatment,MVV,VT and dynamic pulmonary compliance in both groups were significantly improved compared with those before treatment;in the study group,MVV was(80.22±7.14)L/min,VT was(8.91±1.25)ml/kg,dynamic pulmonary compliance was(13.12±2.28)ml/cm H2O(1 cm H2O=0.098 kPa),which were significantly better than(71.12±6.37)L/min,(7.02±1.20)ml/kg,(9.34±2.75)ml/cm H2O in the control group;the difference was statistically significant(P<0.05).After treatment,PaO2 and SaO2 in both groups were significantly improved compared with those before treatment;the study group had PaO2 of(87.22±5.35)mm Hg(1 mm Hg=0.133 kPa)and SaO2 of(96.78±2.31)％,which were significantly better than(53.31±5.26)mm Hg and(93.43±2.12)％in the control group;the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse events between the study group(2.22％)and the control group(6.67％)(P>0.05).Conclusion The use of prone position ventilation for children with pneumonia and respiratory failure can largely improve children's dynamic pulmonary compliance and blood gas parameters,promote faster recovery,and has a good safety profile.
Pneumonia in childrenRespiratory failureProne position ventilationPulmonary dynamic complianceSafety
NETL
NSTL
万方数据
