The clinical efficacy of microwave ablation combined with immunotherapy in the treatment of advanced non-small-cell lung carcinoma
Objective To explore the clinical efficacy of microwave ablation combined with immunotherapy in the treatment of advanced non-small-cell lung carcinoma.Methods A total of 74 patients with advanced non-small-cell lung carcinoma were randomly divided into immune non-ablation group and immune ablation group,with 37 cases in each group.The immune non-ablation group was treated with immunotherapy,and the immune ablation group was treated with microwave ablation on the basis of the immune non-ablation group.The maximum tumor diameter,tumor volume,short-term efficacy,tumor markers and immune indexes were compared between the two groups.Results At 6 months after treatment,the maximum tumor diameter and tumor volume in immune ablation group were(1.58±0.53)cm and(2.36±0.75)cm3,which were significantly smaller than(2.75±0.79)cm and(5.68±0.79)cm3 in immune non-ablation group(P<0.05).The short-term effective rate in immune ablation group(72.97%,27/37)was significantly higher than that in immune non-ablation group(48.65%,18/37)(P<0.05).The disease control rate in immune ablation group(94.59%,35/37)was significantly higher than that in immune non-ablation group(72.97%,27/37)(P<0.05).At 6 months after treatment,the immune ablation group had carcinoembryonic antigen of(5.06±1.38)μg/L,cytokeratin 19 fragment of(4.92±1.23)ng/ml and squamous cell carcinoma antigen of(3.69±1.61)ng/ml,which were significantly lower than(7.91±1.42)μg/L,(6.76±1.69)ng/ml and(4.56±1.68)ng/ml in immune non-ablation group(P<0.05).At 6 months after treatment,the levels of CD3+,CD4+and CD4+/CD8+in immune ablation group were(64.58±8.23)%,(42.57±5.32)%and(1.86±0.45)%,which were significantly higher than(50.15±7.68)%,(34.95±4.63)%and(1.56±0.38)in immune non-ablation group(P<0.05).Conclusion Microwave ablation combined with tislelizumab immunotherapy in the treatment of advanced non-small cell lung cancer can effectively improve the therapeutic effect,accelerate the reduction of tumor size,decrease the level of tumor markers and enhance the immunity of patients,which is worth spreading.
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