Study on clinical efficacy of butylphthalide combined with tenecteplase on patients with acute cerebral infarction and its influence on hs-CRP,Hcy,ESR and prognosis of patient
Objective To explore the clinical efficacy of butylphthalide combined with tenecteplase on patients with acute cerebral infarction and its influence on hypersensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),erythrocyte sedimentation rate(ESR)and prognosis of patient.Methods A total of 100 patients with acute cerebral infarction were selected.They were divided into an experimental group and a control group according to the random number table method,with 50 cases in each group.The patients in both groups were treated with routine antiplatelet,antihypertensive,fluid maintenance and nutritional support.On the basis of these,the experimental group was given butylphthalide plus tenecteplase,and the control group was only given tenecteplase.The clinical efficacy,serum hs-CRP,Hcy and ESR level,National Institutes of Health Stroke Scale(NIHSS)score were compared between the two groups.Results The total clinical effective rate of the experimental group and the control group were 92%(46/50)and 78%(39/50),respectively,and the experimental group was higher than the control group(P<0.05).Compared with before treatment,the serum hs-CRP,Hcy and ESR levels were significantly decreased in both groups after treatment;after treatment,the experimental group had hs-CRP of(4.23±0.84)mg/L,Hcy of(15.14±2.01)μmol/L and ESR of(15.92±1.64)mm/h,which were significantly lower than(7.12±1.08)mg/L,(20.89±2.13)μmol/L and(21.47±2.68)mm/h in the control group(P<0.05).Compared with before treatment,NIHSS score of both groups was significantly decreased after treatment,and the experimental group had significantly lower NIHSS score of(6.57±1.16)points than(9.48±2.19)points of the control group(P<0.05).Conclusion Butylphthalide combined with tenecteplase has become one of the important drugs in the treatment of acute cerebral infarction.This regimen has significant efficacy and safety,can reduce the serum levels of hs-CRP,Hcy,ESR and improve the neurological function,improve the prognosis.
NETL
NSTL
万方数据
