Study on effect of recombinant human brain natriuretic peptide combined with salviae miltiorrhizae and ligustrazine hydrochloride injection on chronic heart failure
Objective To analyze the effect of recombinant human brain natriuretic peptide(rhBNP)combined with salviae miltiorrhizae and ligustrazine hydrochloride injection(SMLI)on chronic heart failure(CHF).Methods 86 patients with CHF were divided into a control group and a study group according to random number table method,with 43 cases in each group.The control group was treated with conventional symptomatic treatment and rhBNP,and the study group was treated with SMLI on the basis of the control group.Both groups were compared in terms of efficacy,cardiac function indexes(left ventricular end-systolic diameter,left ventricular ejection fraction,left ventricular end-diastolic diameter),serological indexes of heart failure(N-terminal pro-brain natriuretic peptide,cardiac troponin I)and adverse reactions.Results The study group had higher total effective rate of 95.35%than 79.07%in the control group(P<0.05).After treatment,the study group had left ventricular end-systolic diameter of(44.65±4.50)mm and left ventricular end-diastolic diameter of(51.67±2.79)mm,which were smaller than(48.70±5.05)and(54.55±2.62)mm in the control group;the study group had higher left ventricular ejection fraction of(44.44±4.80)%than(39.74±3.65)%in the control group(P<0.05).After treatment,the study group had N-terminal pro-brain natriuretic peptide of(828.34±179.40)ng/L and cardiac troponin I of(2.60±0.69)μg/L,which were lower than(970.25±112.32)ng/L and(4.50±0.75)μg/L in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of rhBNP and SMLI in CHF patients has definite curative effect,and can effectively improve the heart function of patients,adjust the serological indexes of heart failure,and has ideal safety and clinical application value.
Recombinant human brain natriuretic peptideSalviae miltiorrhizae and ligustrazine hydrochloride injectionChronic heart failureEfficacy
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