无创正压通气联合法舒地尔治疗慢性肺源性心脏病合并Ⅱ型呼吸衰竭的效果及对内皮因子的影响
The effect of non-invasive positive pressure ventilation combined with fasudil in the treatment of chronic pulmonary heart disease with type Ⅱ respiratory failure and its impact on endothelial factors
吴宝平 1昌伟 1燕飞1
作者信息
摘要
目的 分析无创正压通气(NIPPV)联合法舒地尔治疗慢性肺源性心脏病(CPHD)合并Ⅱ型呼吸衰竭的效果及对内皮因子的影响.方法 选取 82 例CPHD合并Ⅱ型呼吸衰竭患者,使用随机数字表法分为研究组与对照组,每组 41 例.两组均采取常规治疗,对照组使用无创呼吸机进行NIPPV治疗,研究组在对照组基础上联合法舒地尔治疗.比较两组治疗效果、血清内皮因子指标[一氧化氮(NO)与内皮素-1(ET-1)]以及不良反应发生情况.结果 研究组治疗总有效率 95.12%较对照组的 78.05%高(P<0.05).治疗 14 d后,研究组NO水平(59.65±5.02)μmol/L较对照组的(53.65±4.78)μmol/L高,ET-1水平(66.60±4.52)ng/ml较对照组的(75.48±5.03)ng/ml低(P<0.05).两组不良反应发生率比较,结果无差异性(P>0.05).结论 NIPPV联合法舒地尔治疗CPHD合并Ⅱ型呼吸衰竭效果确切,可以有效改善患者的内皮因子,安全性较为理想,具有临床推广价值.
Abstract
Objective To analyze the effect of non-invasive positive pressure ventilation(NIPPV)combined with fasudil in the treatment of chronic pulmonary heart disease(CPHD)with type Ⅱ respiratory failure and its impact on endothelial factors.Methods 82 patients with CPHD and type Ⅱ respiratory failure were divided into a study group and a control group according to random numerical table,each with 41 patients.Both groups received conventional treatment,the control group received NIPPV treatment with non-invasive ventilator,and the study group was treated with fasudil on the basis of the control group.The therapeutic effect,serum endothelial factor indexes[nitric oxide(NO)and endothelin-1(ET-1)]and the occurrence of adverse reactions were compared between the two groups.Results The study group had higher total effective rate of 95.12%than 78.05%in the control group(P<0.05).After 14 d of treatment,the study group had higher NO of(59.65±5.02)μmol/L than(53.65±4.78)μmol/L in the control group,and lower ET-1 of(66.60±4.52)ng/ml than(75.48±5.03)ng/ml in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of NIPPV and fasudil has a definite effect on the treatment of CPHD combined with type Ⅱ respiratory failure,which can improve endothelial factors with ideal safety,and has clinical promotion value.
关键词
无创正压通气/法舒地尔/慢性肺源性心脏病/Ⅱ型呼吸衰竭/内皮因子Key words
Non-invasive positive pressure ventilation/Fasudil/Chronic pulmonary heart disease/TypeⅡ respiratory failure/Endothelial factor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据