The effect of non-invasive positive pressure ventilation combined with fasudil in the treatment of chronic pulmonary heart disease with type Ⅱ respiratory failure and its impact on endothelial factors
Objective To analyze the effect of non-invasive positive pressure ventilation(NIPPV)combined with fasudil in the treatment of chronic pulmonary heart disease(CPHD)with type Ⅱ respiratory failure and its impact on endothelial factors.Methods 82 patients with CPHD and type Ⅱ respiratory failure were divided into a study group and a control group according to random numerical table,each with 41 patients.Both groups received conventional treatment,the control group received NIPPV treatment with non-invasive ventilator,and the study group was treated with fasudil on the basis of the control group.The therapeutic effect,serum endothelial factor indexes[nitric oxide(NO)and endothelin-1(ET-1)]and the occurrence of adverse reactions were compared between the two groups.Results The study group had higher total effective rate of 95.12%than 78.05%in the control group(P<0.05).After 14 d of treatment,the study group had higher NO of(59.65±5.02)μmol/L than(53.65±4.78)μmol/L in the control group,and lower ET-1 of(66.60±4.52)ng/ml than(75.48±5.03)ng/ml in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of NIPPV and fasudil has a definite effect on the treatment of CPHD combined with type Ⅱ respiratory failure,which can improve endothelial factors with ideal safety,and has clinical promotion value.
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