阿米卡星与哌拉西林钠他唑巴坦钠联合治疗老年重症肺炎的效果分析
Effect analysis of amikacin combined with piperacillin sodium and tazobactam sodium in the treatment of severe pneumonia in the elderly
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作者信息
摘要
目的 分析阿米卡星与哌拉西林钠他唑巴坦钠联合治疗老年重症肺炎的效果.方法 98例老年重症肺炎患者,使用随机数字表法分为对照组(49 例)与研究组(49 例).两组患者均采取常规对症治疗,在此基础上,对照组应用哌拉西林钠他唑巴坦钠治疗,研究组应用哌拉西林钠他唑巴坦钠联合阿米卡星治疗.比较两组患者的临床疗效、炎症因子[C反应蛋白(CRP)与降钙素原(PCT)]水平、不良反应发生情况.结果 研究组的治疗总有效率 91.84%高于对照组的 75.51%(P<0.05).治疗前,两组CRP、PCT水平比较,结果无差异性(P>0.05);治疗 10 d后,研究组CRP(20.65±4.89)mg/L、PCT(2.50±1.02)μg/L低于对照组的(35.40±5.00)mg/L、(6.00±1.25)μg/L(P<0.05).两组不良反应发生率未见差异性(P>0.05).结论 阿米卡星与哌拉西林钠他唑巴坦钠联合治疗老年重症肺炎的效果确切,可以有效抑制机体炎症反应,安全性较为理想,适于临床推广.
Abstract
Objective To analyze the effect of amikacin combined with piperacillin sodium and tazobactam sodium in the treatment of severe pneumonia in the elderly.Methods 98 elderly patients with severe pneumonia were selected and randomly divided into a control group(49 cases)and a study group(49 cases).Both groups were treated with conventional symptomatic treatment.On this basis,the control group was treated with piperacillin sodium and tazobactam sodium,and the study group was treated with piperacillin sodium and tazobactam sodium and amikacin.The clinical efficacy,inflammatory cytokines[C-reactive protein(CRP)and procalcitonin(PCT)],and incidence of adverse reactions were compared between two groups of patients.Results The study group had higher total effective rate of 91.84%than 75.51%in the control group(P<0.05).Before treatment,there was no difference in CRP and PCT levels between the two groups(P>0.05).After 10 d of treatment,the study group had CRP of(20.65±4.89)mg/L and PCT of(2.50±1.02)μg/L,which were lower than(35.40±5.00)mg/L and(6.00±1.25)μg/L in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of amikacin and piperacillin sodium and tazobactam sodium is effective in the treatment of severe pneumonia in the elderly,and can effectively inhibit inflammation.The safety of the combination of the two drugs is ideal,which is suitable for clinical promotion.
关键词
阿米卡星/哌拉西林钠他唑巴坦钠/老年/重症肺炎Key words
Amikacin/Piperacillin sodium and tazobactam sodium/Old age/Severe pneumonia引用本文复制引用
出版年
2024
NETL
NSTL
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