Effect analysis of amikacin combined with piperacillin sodium and tazobactam sodium in the treatment of severe pneumonia in the elderly
Objective To analyze the effect of amikacin combined with piperacillin sodium and tazobactam sodium in the treatment of severe pneumonia in the elderly.Methods 98 elderly patients with severe pneumonia were selected and randomly divided into a control group(49 cases)and a study group(49 cases).Both groups were treated with conventional symptomatic treatment.On this basis,the control group was treated with piperacillin sodium and tazobactam sodium,and the study group was treated with piperacillin sodium and tazobactam sodium and amikacin.The clinical efficacy,inflammatory cytokines[C-reactive protein(CRP)and procalcitonin(PCT)],and incidence of adverse reactions were compared between two groups of patients.Results The study group had higher total effective rate of 91.84%than 75.51%in the control group(P<0.05).Before treatment,there was no difference in CRP and PCT levels between the two groups(P>0.05).After 10 d of treatment,the study group had CRP of(20.65±4.89)mg/L and PCT of(2.50±1.02)μg/L,which were lower than(35.40±5.00)mg/L and(6.00±1.25)μg/L in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of amikacin and piperacillin sodium and tazobactam sodium is effective in the treatment of severe pneumonia in the elderly,and can effectively inhibit inflammation.The safety of the combination of the two drugs is ideal,which is suitable for clinical promotion.
AmikacinPiperacillin sodium and tazobactam sodiumOld ageSevere pneumonia
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