Analysis of clinical efficacy of modified Duqi Pill combined with tiotropium bromide in treating stable chronic obstructive pulmonary disease with syndrome of qi deficiency of lung and kidney
Objective To observe the effect of modified Duqi Pill combined with tiotropium bromide in treating stable chronic obstructive pulmonary disease with syndrome of qi deficiency of lung and kidney.Methods 80 patients with chronic obstructive pulmonary disease with syndrome of qi deficiency of lung and kidney were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given tiotropium bromide powder aerosol inhalation treatment,and the observation group was given modified Duqi pill based on the control group.The clinical efficacy after 3 months of treatment,pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC,FEV1 as a percentage of the predicted value],traditional Chinese medicine symptom score and quality of life score before and after treatment.Results After 3 months of treatment,the total effective rate of the observation group and the control group were 92.5%and 70.0%,respectively,and the observation group was significantly higher than the control group.The difference was statistically significant(P<0.05).After treatment,the FVC,FEV1,FEV1/FVC and FEV1 as a percentage of the predicted value in both groups were higher than those before treatment;the observation group had FEV1 of(1.93±0.19)L,FVC of(2.85±0.31)L,FEV1/FVC of(65.21±7.05)%,and FEV1 as a percentage of the predicted value of(67.68±7.09)%,which were higher than(1.74±0.17)L,(2.69±0.29)L,(59.31±6.91)%,and(60.74±6.93)%in the control group;the difference was statistically significant(P<0.05).After treatment,the scores of dyspnea and shortness of breath,fatigue,spontaneous sweating,susceptibility to colds,lower back and knee soreness,and nocturia frequency in both groups were lower than those before treatment;in the observation group,the scores of dyspnea and shortness of breath,fatigue,spontaneous sweating,susceptibility to colds,lower back and knee soreness,and nocturia frequency were(0.74±0.54),(0.81±0.23),(1.24±0.29),(1.58±0.34),(0.84±0.51),and(0.88±0.54)points,which were lower than(1.05±0.64),(1.07±0.24),(1.65±0.33),(1.77±0.41),(1.12±0.26),and(1.31±0.37)points in the control group;the difference was statistically significant(P<0.05).After treatment,the scores of physical function,cognitive function,emotional function and social function in both groups were higher than those before treatment;in the observation group,the score of physical function was(89.59±10.21),the score of cognitive function was(87.23±10.09),the score of emotional function was(85.17±10.01)and the score of social function was(89.34±10.31)points,which were higher than(77.33±10.39),(79.22±10.08),(72.39±10.13)and(70.88±10.11)points in the control group;the difference was statistically significant(P<0.05).Conclusion The clinical application of modified Duqi Pill combined with tiotropium bromide has a definite effect in patients with stable chronic obstructive pulmonary disease with syndrome of qi deficiency of lung and kidney,which can significantly reduce the scores of various traditional Chinese medicine syndromes of patients,improve the lung ventilation function of patients.It is helpful to improve the quality of life of patients,and has a wide clinical application prospect.
Modified Duqi PillTiotropium bromideStable stageChronic obstructive pulmonary diseaseSyndrome of qi deficiency of lung and kidneyClinical efficacy
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