Effect analysis of intravenous thrombolysis with tenecteplase and sequential tirofiban intravenous pumping in the treatment of acute cerebral infarction
Objective To explore the effect of intravenous thrombolysis with tenecteplase and sequential tirofiban intravenous pumping in the treatment of acute cerebral infarction.Methods 68 patients with acute cerebral infarction were selected as the research subjects of this study,and they were divided into a study group and a control group according to random allocation method,with 34 patients in each group.After admission,all patients were given intravenous thrombolysis with tenecteplase,the control group was treated with aspirin 24 h after intravenous thrombolytic therapy,while the study group was treated with tirofiban intravenous pumping immediately after intravenous thrombolytic therapy.The levels of neuron-specific enolase,S100β protein,neurological impairment score and incidence of adverse reactions were compared between the two groups.Results In the study group,the neuron-specific enolase level,S100β protein level and neurological impairment score of patients were(16.24±2.41)ng/ml,(1.25±0.27)μg/L and(3.25±1.26)points,which were significantly lower than(18.75±1.43)ng/ml,(1.68±0.39)μg/L and(6.26±1.85)points in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse events in the study group was 5.88%,which was significantly lower than 23.53%in the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with acute cerebral infarction,intravenous thrombolytic therapy with tenecteplase and sequential tirofiban intravenous pumping can effectively reduce the level of neuron-specific enolase,S100β protein,neurological impairment score and incidence of adverse reactions,and is worthy of wide application.
Acute cerebral infarctionIntravenous thrombolysis with tenecteplaseTirofiban
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