Study on effect of non-invasive positive pressure ventilation on arterial blood gas parameters and serum inflammatory factors in patients with chronic obstructive pulmonary disease complicated with respiratory failure
Objective To explore the effect of non-invasive positive pressure ventilation on arterial blood gas parameters and serum inflammatory factors in patients with chronic obstructive pulmonary disease complicated with respiratory failure.Methods 60 patients with chronic obstructive pulmonary disease complicated with respiratory failure were selected as the study subjects,and divided into an observation group(30 cases)and a control group(30 cases)according to random number table method.The control group was given conventional regimen,the observation group was given non-invasive positive pressure ventilation treatment based on the basis of the control group.Patients in both groups were compared in terms of arterial blood gas parameters[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),and blood oxygen saturation(SaO2)],cardiac function indexes[left ventricular ejection fraction(LVEF)and cardiac troponin I(cTnI)N-terminal pro-B-type natriuretic peptide(NT proBNP)]and serum inflammatory factors[serum C-reactive protein(CRP),interleukin-6(IL-6),and transforming growth factor-β1(TGF-β1)]before and after treatment.Results Compared with before treatment,PaO2 and SaO2 increased and PaCO2 decreased in the two groups after treatment;after treatment,the observation group had PaO2 of(81.54±7.42)mm Hg(1 mm Hg=0.133 kPa)and SaO2 of(93.53±6.22)%,which were higher than(72.75±7.37)mm Hg and(85.17±5.76)%in the control group;the observation group had lower PaCO2 of(44.25±7.14)mm Hg than(52.33±7.26)mm Hg in the control group(P<0.05).Compared with before treatment,LVEF increased in both groups after treatment,while serum cTnI and NT-proBNP levels decreased;after treatment,the observation group had higher LVEF than that in the control group,and lower cTnI and NT-proBNP levels than those in the control group(P<0.05).Compared with before treatment,the serum levels of CRP,IL-6 and TGF-β1 decreased in both groups after treatment;after treatment,the observation group had serum CRP of(8.68±2.14)mg/L,IL-6 of(14.66±3.44)pg/ml and TGF-β1 of(99.43±12.63)ng/L,which were lower than(23.41±3.69)mg/L,(30.28±5.17)pg/ml and(118.52±12.75)ng/L in the control group(P<0.05).Conclusion Non-invasive positive pressure ventilation can improve the arterial blood gas and cardiac function in patients with chronic obstructive pulmonary disease complicated with respiratory failure,and reduce inflammation,thus promoting the recovery of patients.
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