Effect of low-temperature plasma ablation under nasal endoscopy in the treatment of obstructive sleep apnea-hypopnea syndrome in children and its influence on their immune function
Objective To explore the effect of low-temperature plasma ablation under nasal endoscopy in the treatment of obstructive sleep apnea-hypopnea syndrome in children and its influence on their immune function.Methods 70 children with obstructive sleep apnea hypopnea syndrome were divided into a control group and an observation group according to random number table,with 35 cases in each group.Children in the control group were treated with nasal dynamic incision,and children in the observation group were treated with low-temperature plasma ablation under nasal endoscopy.Both groups were compared in terms of surgical indexes,immune function indexes,disease specific quality of life for children with obstructive sleep apnea 18 items survey(OSA-18)score,apnea hypopnea index(AHI),lowest oxygen saturation(LSaO2)and maximum tympanic pressure difference before and after surgery,clinical efficacy and postoperative complications.Results The intraoperative blood loss in the observation group was(9.12±2.28)ml,which was significantly less than(28.84±2.02)ml in the control group(t=38.300,P<0.05).The total operation time of the observation group was(19.24±5.02)min,which was significantly shorter than(36.58±4.24)min of the control group(t=15.612,P<0.05).2 weeks after surgery,the levels of IgA,IgG,IgM,CD3+,CD4+and CD4+/CD8+in both groups were lower than those before surgery;the observation group had IgA of(1.16±0.06)g/L,IgG of(9.78±0.95)g/L,IgM of(1.24±0.05)g/L,CD3+of(60.44±3.67)%,CD4+of(31.11±3.18)%and CD4+/CD8+of(1.10±0.15),which were lower than(1.32±0.08)g/L,(10.26±1.02)g/L,(1.46±0.10)g/L,(63.63±4.23)%,(33.63±3.06)%and(1.18±0.10)in the control group(P<0.05).6 months after surgery,OSA-18 score and AHI in both groups were lower than those before surgery,and LSaO2 and maximum tympanic pressure difference were higher than those before surgery(P<0.05).6 months after surgery,the observation group had OSA-18 score of(32.76±3.42)points and AHI of(5.35±1.18)times/h,which were lower than(36.25±3.83)points and(7.86±1.14)times/h in the control group;the observation group had LSaO2 of(93.24±5.76)%and maximum tympanic pressure difference of(24.46±5.56)daPa,which were higher than(83.24±5.56)%and(20.48±4.45)daPa in the control group(P<0.05).There was no difference in the total effective rate between the two groups(χ2=0.348,P>0.05).The total incidence of postoperative complications in the control group was 17.14%;there were no postoperative complications in the observation group,and the total incidence of postoperative complications in the observation group was 0;the total incidence of postoperative complications in the observation group was lower than that in the control group(χ2=6.563,P<0.05).Conclusion Compared with nasal dynamic incision,low-temperature plasma ablation under nasal endoscopy in the treatment of obstructive sleep apnea-hypopnea syndrome in children can effectively shorten the operation time and reduce intraoperative blood loss,improve the immune function and eustachian tube function of children,reduce postoperative complications,and improve the quality of life of children.
Obstructive sleep apnea-hypopnea syndromeNasal endoscopyAdenoid Low-temperature plasma ablationImmune function
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