Analysis of the clinical effect of sildenafil combined with high-frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension in neonates
Objective To explore the clinical effect of sildenafil combined with high-frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension in neonates.Methods A total of 50 neonates with persistent pulmonary hypertension were divided into a control group and an observation group by random number table method,each with 25 cases.Both groups were given conventional symptomatic treatment.On this basis,the control group was treated with simple high frequency oscillation ventilation,and the observation group was treated with high frequency oscillation ventilation+sildenafil.The total effective rate,blood gas index,pulmonary arterial pressure and incidence of adverse reactions were compared between the two groups.Results The total effective rate was 96.0%in the observation group,which was higher than 76.0%in the control group,and there was statistical significance(P<0.05).After treatment,the oxygen partial pressure of the observation group was(85.52±4.87)mm Hg(1 mm Hg=0.133 kPa),and the blood oxygen saturation was(92.52±3.8)%,which were higher than(70.55±4.64)mm Hg and(85.58±3.19)%of the control group;the partial pressure of carbon dioxide in the observation group was(38.52±4.22)mm Hg,which was lower than(47.41±4.69)mm Hg in the control group;there was statistical significance(P<0.05).The pulmonary artery pressure after treatment in both groups was lower than that before treatment,and the difference was statistically significant(P<0.05).After treatment,the pulmonary artery pressure was(24.87±3.26)mm Hg in the observation group,which was lower than(37.95±3.88)mm Hg in the control group,and there was statistical significance(P<0.05).The incidence of adverse reactions in the observation group was not statistically significant compared with control group(P>0.05).Conclusion Sildenafil combined with high frequency oscillatory ventilation in the treatment of neonates with persistent pulmonary hypertension has significant clinical efficacy and is worth popularizing.
NETL
NSTL
万方数据
