目的 评价急性间质性肾炎(AIN)应用泼尼松治疗的临床效果。方法 选择急性间质性肾炎患者 80 例，采用随机数字表法分为对照组和观察组，各 40 例。对照组行常规对症治疗，观察组在对照组基础上配合泼尼松治疗。对比两组患者临床疗效、生活质量评分及治疗前后肾功能指标[血尿素氮(BUN)、血肌酐(SCr)、尿β2 微球蛋白(β2-MG)、24 h 尿蛋白定量(24 h UP)、尿酸(UA)]。结果 观察组总有效率 95。00%高于对照组的 80。00%(P<0。05)。观察组躯体功能、躯体角色、机体疼痛、总体健康、活力、社会功能、情绪角色、心理健康评分分别为(90。03±3。30)、(91。30±2。30)、(91。05±2。35)、(91。30±3。20)、(91。80±2。80)、(92。20±3。15)、(91。02±3。15)、(92。20±3。30)分，均明显高于对照组的(84。40±2。50)、(85。50±2。20)、(86。02±2。22)、(85。50±2。60)、(86。50±2。30)、(86。60±2。60)、(86。50±2。55)、(86。60±2。30)分(P<0。05)。治疗后，两组BUN、SCr、β2-MG、24 h UP、UA水平均较治疗前下降，且观察组治疗后BUN(6。66±1。88)mmol/L、SCr(215。70±5。50)μmol/L、β2-MG(0。25±0。10)mg/L、24 h UP(0。38±0。30)g/24 h、UA(339。40±9。01)μmol/L均低于对照组的(10。20±2。60)mmol/L、(410。50±8。80)μmol/L、(0。36±0。15)mg/L、(1。22±0。40)g/24 h、(444。02±9。50)μmol/L(P<0。05)。结论 泼尼松治疗急性间质性肾炎的临床效果显著，可促进患者肾功能改善，且能提升患者的生活质量。
Clinical efficacy of prednisone in the treatment of acute interstitial nephritis
Objective To evaluate the clinical effect of prednisone in the treatment of acute interstitial nephritis(AIN).Methods A total of 80 patients with acute interstitial nephritis were selected and divided into a control group and an observation group by random number table method,with 40 cases in each group.The control group received conventional symptomatic treatment,and the observation group was treated with prednisone on the basis of the control group.Patients in both groups were compared in terms of clinical efficacy,quality of life score and renal function indexes[blood urea nitrogen(BUN),serum creatinine(SCr),urinary β2-microglobulin(β2-MG),24 h urinary protein quantity(24 h UP),uric acid(UA)]before and after treatment.Results The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05).The scores of physical function,role-physical,body pain,general health,vitality,social function,role-emotional and mental health in the observation group were(90.03±3.30),(91.30±2.30),(91.05±2.35),(91.30±3.20),(91.80±2.80),(92.20±3.15),(91.02±3.15)and(92.20±3.30)points,which were significantly higher than(84.40±2.50),(85.50±2.20),(86.02±2.22),(85.50±2.60),(86.50±2.30),(86.60±2.60),(86.50±2.55)and(86.60±2.30)points in the control group(P<0.05).After treatment,BUN,SCr,β2-MG,24 h UP and UA levels in both groups were decreased compared with those before treatment;the observation group had BUN of(6.66±1.88)mmol/L,SCr of(215.70±5.50)μmol/L,β2-MG of(0.25±0.10)mg/L,24 h UP of(0.38±0.30)g/24 h,and UA of(339.40±9.01)μmol/L,which were lower than(10.20±2.60)mmol/L,(410.50±8.80)μmol/L,(0.36±0.15)mg/L,(1.22±0.40)g/24 h and(444.02±9.50)μmol/L in the control group(P<0.05).Conclusion Prednisone has significant clinical effect in the treatment of acute interstitial nephritis,and can promote the improvement of renal function and improve the quality of life of patients.
NETL
NSTL
万方数据
