Efficacy of nifedipine combined with metformin in general treatment of hypertension
Objective To analyze the clinical effect of nifedipine combined with metformin in general treatment of hypertension.Methods All 20 patients with hypertension were treated with nifedipine combined with metformin.The blood pressure,blood glucose,blood lipids,vascular endothelial function and blood rheology level before and after treatment,clinical efficacy and occurrence of adverse reactions were compared.Results Before treatment,the systolic blood pressure was(162.38±5.17)mm Hg(1 mm Hg=0.133 kPa),the diastolic blood pressure was(101.25±2.74)mm Hg,the fasting blood glucose was(10.38±1.74)mmol/L,the 2 h postprandial blood glucose was(14.38±2.43)mmol/L,the glycosylated hemoglobin was(4.26±0.49)%,the total cholesterol was(5.42±1.39)mmol/L,the triglyceride was(2.86±1.15)mmol/L,the low-density lipoprotein cholesterol was(3.74±0.39)mmol/L and the high-density lipoprotein cholesterol was(1.05±0.11)mmol/L.After treatment,the systolic blood pressure was(137.15±3.49)mm Hg,the diastolic blood pressure was(79.25±2.43)mm Hg,the fasting blood glucose was(6.27±0.63)mmol/L,the 2 h postprandial blood glucose was(9.25±0.76)mmol/L,the glycosylated hemoglobin was(3.12±0.16)%,the total cholesterol was(4.16±0.49)mmol/L,the triglyceride was(1.42±0.36)mmol/L,the low density lipoprotein cholesterol was(2.49±0.16)mmol/L and the high density lipoprotein cholesterol was(1.39±0.19)mmol/L.Compared with before treatment,the systolic blood pressure,diastolic blood pressure,fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride and low density lipoprotein cholesterol all decreased after treatment,while the high density lipoprotein cholesterol increased,and there was statistical difference(P<0.05).Before treatment,the nitric oxide(NO)was(24.39±2.76)μmol/L,the vascular endothelial growth factor(VEGF)was(24.76±2.79)pg/ml,the endothelin-1(ET-1)was(79.26±11.25)ng/L,the whole blood viscosity was(2.16±0.34)mPa·s,the whole blood low shear viscosity was(28.43±1.77)mPa·s,the whole blood high shear viscosity was(8.46±0.95)mPa·s,and the erythrocyte aggregation index was(3.36±0.16).After treatment,NO was(28.36±4.19)μmol/L,VEGF was(31.28±2.49)pg/ml,ET-1 was(64.26±7.26)ng/L,the whole blood viscosity was(1.82±0.16)mPa·s,the whole blood low shear viscosity was(20.36±1.43)mPa·s,the whole blood high shear viscosity was(6.25±0.49)mPa·s,the erythrocyte aggregation index was(3.26±0.13).Compared with before treatment,NO and VEGF were increased,while ET-1,whole blood viscosity,whole blood low shear viscosity,whole blood high shear viscosity,and erythrocyte aggregation index were decreased,and there was statistical difference(P<0.05).Of the 20 patients,12(60.00%)were significantly effective,7(35.00%)were effective,and 1(5.00%)were ineffective.The total effective rate was 95.00%(19/20).3 patients had headache,2 patients had flushing,and 1 patient had mild hypoglycemia.All patients showed no signs of aggravation of adverse reactions after symptomatic treatment,and no drug was stopped due to adverse drug reactions.Conclusion The application of antihypertensive drug nifedipine combined with hypoglycemic drug metformin in the general practice treatment of hypertensive patients can effectively improve the patients'blood pressure and glucose-lipid metabolism,and at the same time regulate the function of the vascular endothelium and blood rheology,which is conducive to the improvement of the clinical therapeutic effect,and can be further popularized in the clinic.
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