Observation on the effect of modified Xiaoke Yishen decoction on patients with early type 2 diabetic kidney disease and proteinuria
Objective To observe the effect of modified Xiaoke Yishen decoction on patients with early type 2 diabetic kidney disease(T2DKD)and proteinuria.Methods 160 patients with early T2DKD and proteinuria were randomly divided into an observation group and a control group,with 80 patients in each group.The control group was given conventional symptomatic treatment of Western medicine,and the observation group was given modified Xiaoke Yishen decoction on the basis of the treatment of the control group.The clinical effect,urine microalbumin-to-urinary creatinine ratio(UACR)and estimated glomerular filtration rate(eGFR)levels,blood pressure,blood lipid and blood glucose levels after treatment were compared between the two groups.Results After treatment,the total effective rate was 85.00%in the observation group,which was significantly higher than 71.25%in the control group(P<0.05).After treatment,UACR was(47.0±17.5)mg/g in the observation group,which was significantly lower than(68.0±14.5)mg/g in the control group(P<0.05).There was no significant difference in eGFR levels between the two groups(P>0.05).After treatment,the fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),systolic blood pressure(SBP)and diastolic blood pressure(DBP)in the observation group were(6.3±1.6)mmol/L,(7.6±1.4)%,(3.3±1.3)mmol/L,(2.1±0.7)mmol/L,(116.4±10.9)mm Hg(1 mm Hg=0.133 kPa)and(74.9±11.7)mm Hg,which were lower than(7.4±2.4)mmol/L,(9.0±2.1)%,(4.7±1.2)mmol/L,(2.7±0.7)mmol/L,(138.2±15.2)mm Hg and(86.6±12.7)mm Hg in the control group(P<0.05).Conclusion The modified Xiaoke Yishen decoction shows definite efficacy for patients with early T2DKD and proteinuria,which can obviously relieve the clinical symptoms,improve the renal function and lower the blood sugar of the patients,so it can be used in clinical promotion.
Early type 2 diabetic kidney diseaseProteinuriaGlomerular filtration rateRenal functionXiaoke Yishen decoction
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