Analysis of 1115 adverse drug reaction reports in a hospital
Objective To understand the pattern and characteristics of ADR occurrence by analyzing the adverse drug reactions(ADR)reports in a tertiary hospital in Guangdong Province,so as to provide reference for clinical safe drug use and better guarantee the safety of public drug use.Methods Selecting 1115 ADR reports reported by the Pharmacy Department of Zhaoqing First People's Hospital to the National Adverse Drug Reaction Monitoring Center,a retrospective study method was used to statistically analyze these 1115 ADRs from gender and age distribution,drug types,antibacterial drug distribution,administration routes,and involved organ systems.Results Of the 1115 ADR cases reported,526 cases(47.2%)were male and 589 cases(52.8%)were female,with a male-to-female ratio of 0.89:1,and the incidence of ADR in elderly patients(>60 years old)was 45.1%,accounting for the highest proportion.ADR involved 14 types of drugs,of which the type with the most ADR was antitumor drugs(25.2%),followed by anti-infective drugs(21.5%).Among the anti-infective drugs,cephalosporins accounted for the highest proportion of 32.9%,followed by quinolones(23.8%)and penicillins(19.6%).Intravenous administration had the highest frequency of ADR at 73.8%,followed by oral administration at 14.8%.ADRs most frequently involved the skin and its adnexal damage in 29.8%,followed by the hematologic system in 28.0%.Conclusion The occurrence of ADR is related to various factors such as the patient's gender,age,type of medication,and route of administration.Hospitals should strengthen the monitoring and management of ADR,standardize the rational use of drugs,and ensure the safety of patient medication.
Adverse drug reactionsMedication safetyIntravenous medicationAntitumor drugsAntibacterial drugs
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