Analysis of the application effect of iron sucrose combined with recombinant human erythropoietin injection in patients with chronic renal failure and renal anemia
Objective To analyze the application value of iron sucrose combined with recombinant human erythropoietin injection in patients with chronic renal failure and renal anemia.Methods A total of 80 patients with chronic renal failure and renal anemia were selected and divided into a control group(40 cases,treated with recombinant human erythropoietin injection)and an observation group(40 cases,treated with iron sucrose combined with recombinant human erythropoietin injection)by random number table method.The clinical efficacy,incidence of adverse reactions,hematological parameters,iron index,renal function index and quality of life score before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the observation group had red blood cell count(RBC)of(2.98±0.21)×1012/L,hemoglobin(Hb)of(88.25±3.95)g/L,and hematocrit(HCT)of(25.13±3.53)%,which were higher than(2.58±0.29)×1012/L,(75.04±3.71)g/L,and(22.40±2.96)%in the control group(P<0.05).After treatment,the serum iron(SI),serum ferritin(SF)and transferin saturation(TAST)of the observation group were better than those of the control group(P<0.05).After treatment,the observation group had blood urea nitrogen(BUN)of(8.62±2.03)mmol/L,serum creatinine(Scr)of(176.36±14.50)μmol/L,and blood uric acid of(450.42±65.30)μmol/L,which were lower than(13.39±2.19)mmol/L,(232.60±18.34)μmol/L,and(562.97±98.21)μmol/L of the control group(P<0.05).After treatment,the scores of physical activity,sleep,pain,social loneliness,emotional response and energy in the observation group were(8.27±1.97),(10.97±1.78),(10.42±1.49),(8.31±1.42),(9.30±1.30)and(8.47±1.65)points,which were significantly lower than(12.69±2.04),(14.59±2.39),(13.93±1.78),(11.48±2.64),(13.39±2.58)and(13.40±2.38)points in the control group(P<0.05).Conclusion For patients with chronic renal failure combined with renal anemia,the combination of iron sucrose and recombinant human erythropoietin injection is beneficial for improving clinical efficacy,enhancing iron absorption,and significantly improving renal function and quality of daily life in patients.It has high therapeutic value and is worth promoting.
Iron sucroseRecombinant human erythropoietin injectionChronic renal failureRenal anemia
NETL
NSTL
万方数据
