Correlation analysis of red blood cell distribution width,glycosylated hemoglobin level with the degree of coronary artery disease and stenosis in patients with unstable angina pectoris
Objective To analyze the correlation of red blood cell distribution width,glycosylated hemoglobin level with the degree of coronary artery disease and stenosis in patients with unstable angina pectoris.Methods 120 patients with unstable angina pectoris were divided into single-vessel lesion group(60 patients),double-vessel lesion group(40 patients)and multi-vessel lesion group(20 patients)according to the number of coronary artery lesions.According to the different degree of coronary artery stenosis,they were divided into mild stenosis group(50 cases),moderate stenosis group(40 cases),severe stenosis group(20 cases)and complete occlusion group(10 cases).The red blood cell distribution width and the level of glycosylated hemoglobin level in the groups with different numbers of coronary artery lesions and degree of stenosis were compared.Pearson method was used to analyze the correlation of red blood cell distribution width,glycosylated hemoglobin level with the number of coronary artery lesions and the degree of coronary artery stenosis.Results The red blood cell distribution width in the single-vessel lesion group,double-vessel lesion group,and multi-vessel lesion group were(9.27±0.71)%,(12.59±1.36)%,and(17.87±2.68)%,and the glycosylated hemoglobin were(6.57±1.12)%,(8.89±2.06)%,and(12.65±3.18)%.Comparison of red blood cell distribution width and glycosylated hemoglobin levels in the single-vessel lesion group,double-vessel lesion group,and multi-vessel lesion group showed statistically significant differences(P<0.05).The red blood cell distribution width and glycosylated hemoglobin level from high to low were:multi-vessel lesion group>double-vessel lesion group>single-vessel lesion group,and the difference was statistically significant(P<0.05).The red blood cell distribution width in the mild stenosis group,moderate stenosis group,severe stenosis group,and complete occlusion group were(8.71±0.63)%,(11.86±0.92)%,(15.76±1.78)%,and(20.36±3.04)%,and the glycosylated hemoglobins were(5.47±1.15)%,(6.97±1.83)%,(9.22±2.68)%,and(14.86±3.89)%.Comparison of red blood cell distribution width and glycosylated hemoglobin levels in the mild stenosis group,moderate stenosis group,severe stenosis group,and complete occlusion group showed statistically significant differences(P<0.05).The red blood cell distribution width and glycosylated hemoglobin level from high to low were:complete occlusion group>severe stenosis group>moderate stenosis group>mild stenosis group,and the difference was statistically significant(P<0.05).Pearson analysis showed that the number of coronary artery lesions in patients with unstable angina pectoris was positively correlated with the red blood cell distribution width and the glycosylated hemoglobin level(r=0.25,0.15;P<0.05).The degree of coronary artery stenosis was positively correlated with the red blood cell distribution width and glycosylated hemoglobin level(r=0.49,0.65;P<0.05).Conclusion The number of coronary artery lesions and the degree of stenosis in patients with unstable angina pectoris can be evaluated by serological detection of red blood cell distribution width and glycocated hemoglobin level,and clinical treatment can be guided according to the severity of the patient's condition,so as to obtain a better prognosis for the patients.
Red blood cell distribution widthUnstable angina pectorisGlycosylated hemoglobinDegree of coronary artery diseaseCorrelation analysis
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NSTL
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