Objective To evaluate the prognostic effect and safety of atorvastatin calcium in the treatment of acute cerebral infarction(ACI).Methods 106 ACI patients were selected and randomly divided into a control group(n=53,treated with simvastatin)and an observation group(n=53,treated with atorvastatin calcium tablets).The clinical efficacy,adverse drug reactions,degree of neurological impairment,and rehabilitation were compared between the two groups.Results The total effective rate of the observation group was 96.23%,which was higher than 81.13%of control group,and the difference was significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score in both groups was lower than that before treatment,and the NIHSS score of(4.55±1.20)points in the observation group was lower than(5.60±1.40)points in the control group.The difference was significant(P<0.05).After treatment,the levels of oxidized low-density lipoprotein(ox-LDL)and hypersensitive C-reactive protein(hs-CRP)in both groups were lower than those before treatment;the observation group had ox-LDL of(46.78±4.45)μg/dl and hs-CRP of(3.22±1.01)mg/L,which were lower than(57.32±4.55)μg/dl and(8.72±1.20)mg/L in the control group;the difference was significant(P<0.05).Conclusion Atorvastatin calcium tablets are safe and effective in the treatment of ACI,and can promote the improvement of neurological function and clinical recovery in patients.
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