Clinical effects of terbutaline and budesonide sequential aerosol inhalation on the pulmonary function and immune cells for patients with acute attack of bronchial asthma
Objective To analyze the effects of terbutaline and budesonide sequential aerosol inhalation on the pulmonary function and immune cells for patients with acute attack of bronchial asthma.Methods 86 patients with acute attack of bronchial asthma were selected.According to different therapies,patients were assigned to a control group and a study group,each with 43 patients.The terbutaline and budesonide aerosol inhalation was performed in the control group;the terbutaline and budesonide sequential aerosol inhalation was performed in the study group.The disappearance time of clinical symptoms,pulmonary function indicators,and immune cytokines were compared between two groups of patients.Results The disappearance time of cough,chest tightness,wheezing rales and asthma were(5.68±1.38),(3.74±0.68),(4.13±1.87)and(2.13±0.57)d in the study group,which were shorter than(7.42±2.06),(5.86±0.91),(5.57±2.19)and(4.62±1.38)d in the control group,and the difference was statistically significant(P<0.05).After 1 week of treatment,the forced expiratory volume in one second as a percentage of the predicted value(FEV1%)of the study group was(90.66±8.90)%and the peak expiratory flow rate as a percentage of the predicted value was(81.47±5.53)%,which were higher than(82.15±8.71)%and(66.79±5.34)%in the control group.The difference was statistically significant(P<0.05).After 1 week of treatment,the study group had CD3+of(62.78±3.47)%,CD4+of(40.24±3.28)%and CD4+/CD8+of(1.62±0.21),which were higher than(57.74±3.24)%,(35.56±3.13)%and(1.31±0.24)in the control group;the study group had CD8+of(25.02±2.18)%,which was lower than(27.22±2.57)%in the control group;the difference was statistically significant(P<0.05).Conclusion For patients with acute attack of bronchial asthma,terbutaline and budesonide sequential aerosol inhalation shows active significance,which can effectively improve the pulmonary function and immune cytokines patients.It has clinical promotion value.
TerbutalineBudesonideSequential aerosol inhalationAcute attack of bronchial asthmaPulmonary functionImmune cells
NETL
NSTL
万方数据
