Effects of risperidone combined with folic acid on brain-derived neurotrophin factor and inflammatory cytokines in patients with schizophrenia
Objective To observe the effects of risperidone combined with folic acid on brain-derived neurotrophin factor and inflammatory cytokines in patients with schizophrenia.Methods 85 patients with first-episode schizophrenia were divided into a control group(42 patients)and a study group(43 patients)according to randomized parallel control method.The control group was treated with risperidone,while the study group was treated with folic acid and risperidone.Both groups were compared in terms of inflammatory cytokines[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],brain-derived neurotrophic factor(BDNF),homocysteine(Hcy),degree of schizophrenia[Positive and Negative Symptom Scale(PANSS)score],violent behavior[Modified Overt Aggression Scale(MOAS)score],and cognitive function[Wechsler Adult Intelligence Scale-Revised in China(WAIS-RC)score],and social function[Scale of Social Function in Psychosis Inpatients(SSPI)score].Results After 3 months of treatment,the levels of IL-6 and TNF-α in the study group were(33.86±3.07)and(26.93±2.38)pg/ml,which were significantly lower than(38.15±3.56)and(32.67±2.93)pg/ml in the control group(P<0.05).After 3 months of treatment,the study group had higher BDNF of(593.18±56.02)pg/ml than(527.46±49.37)pg/ml in the control group,and lower Hcy of(28.76±2.54)μmol/L than(34.13±3.15)μmol/L in the control group(P<0.05).After 3 months of treatment,the PANSS and MOAS scores of the study group were(53.62±5.04)and(8.95±0.86)points,which were significantly lower than(60.97±5.75)and(10.27±0.98)points of the control group(P<0.05).After 3 months of treatment,the WAIS-RC and SSPI scores of the study group were(206.91±17.85)and(33.25±3.01)points,which were higher than(185.26±15.37)and(28.07±2.54)points of the control group(P<0.05).Conclusion Risperidone combined with folic acid can improve the levels of BDNF and inflammatory cytokines,alleviate the clinical symptoms and violence of patients with schizophrenia,improve their cognitive function and social function,which has a better therapeutic effect.
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