Research progress of dissociated responses related to immunotherapy for solid tumors
In recent years,immune checkpoint inhibitors(ICIs)have been widely used in clinical practice at home and abroad,which have greatly improved the survival and prognosis of some patients with advanced malignant tumors.After immunotherapy,some patients will have a co-existence of responsive and non-responsive lesions,that is,dissociative reactions(DR).At present,the specific mechanism of DR has not been clarified,and the evaluation criteria vary,which increases the challenge for clinicians to identify and treat patients in a timely manner.In this paper,the definition,incidence,evaluation criteria and potential biological mechanisms of immunotherapy-related dissociated reactions are systematically reviewed in order to provide reference for clinical practice.
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