The correlation of Chlamydia trachomatis and Ureaplasma urealyticum infection with human papillomavirus infection and cervical lesions
Objective To analyze the correlation of Chlamydia trachomatis(CT)and Ureaplasma urealyticum infection with human papillomavirus(HPV)infection and cervical lesions.Methods 400 patients with cervical lesions were divided into cervicitis group(200 cases),cervical intraepithelial neoplasia group(CIN group,183 cases),and cervical malignancy group(17 cases)according to pathological diagnosis.All patients underwent cervical screening and detection of genital tract pathogens and routine leucorrhea,and patients with abnormal cervical screening were further treated according to the diagnostic and therapeutic specifications.The HPV typing and infection of patients with cervical lesions,and the infection of genital tract pathogens were analyzed,as well as the correlation between genital tract pathogens infection and HPV infection.Results(i)Out of the 400 patients,182 cases had HPV infection,of which 24 cases were cervicitis with HPV infection,accounting for 13.19%,and 158 cases were CIN,cervical malignancy combined with HPV infection,accounting for 86.81% .Among the 182 patients,high-risk HPV infections were predominant,and HPV types 16,52 and 58 were the more common genotypes.There were 141 cases of single HPV infection,accounting for 77.47%,and 41 cases of multiple HPV infection,accounting for 22.53% .With increasing severity of cervical lesions,the rate of single HPV infection gradually increased,and the difference in the single HPV infection rate between the cervicitis group,CIN group,and cervical malignancy group was statistically significant(P<0.05).With increasing severity of cervical lesions,the multiple HPV infection rate had a tendency to increase and then decrease,and the difference in the multiple HPV infection rate between the cervicitis group,CIN group,and cervical malignancy group was statistically significant(P<0.05).(ii)Among the 400 patients,154 cases were infected with genital tract pathogens,the infection rate was 38.50%,including 32.00% (64/200)in the cervicitis group,44.81% (82/183)in the CIN group,and 47.06% (8/17)in the cervical malignancy group.The difference was statistically significant(P<0.05).(iii)Univariate analysis showed that the difference in HPV positive rate between Chlamydia trachomatis,Ureaplasma urealyticum(Uu),Ureaplasma parvum(Up),and Mycoplasma hominis-positive and negative patients was statistically significant(P<0.05).Logistic regression analysis showed that Chlamydia trachomatis,Ureaplasma urealyticum,Ureaplasma parvum,and Mycoplasma hominis infections were risk factors for HPV infection(P<0.05).Conclusion Analyzing the relevant information of patients with different degrees of cervical lesions shows that single and high-risk HPV infection is the most common type,while HPV16,HPV52,and HPV58 are common genotypes.The infection rates of Chlamydia trachomatis and Ureaplasma urealyticum are significantly higher in patients with CIN or cervical malignancy.Genital tract infections of mycoplasma and Chlamydia infection increase the risk of HPV infection,and attention should be paid to screening both to prevent HPV infection.
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