Effect of aspirin combined with rosuvastatin on the therapeutic effect and biochemical indexes of patients with<50%coronary artery stenosis
Objective To explore the effect of aspirin combined with rosuvastatin on the therapeutic effect and biochemical indexes of patients with<50% coronary artery stenosis.Methods 86 patients with<50% coronary artery stenosis were randomly divided into a control group(43 cases,rosuvastatin treatment)and a combination group(43 cases,aspirin combined with rosuvastatin treatment).The clinical efficacy,lipid metabolism indexes,serum inflammatory markers,carotid ultrasound indicators and cardiovascular events were compared between the two groups.Results The total effective rate of 97.67% in the combination group was higher than 83.72% in the control group(P<0.05).After treatment,the serum total cholesterol,triglyceride and low density lipoprotein cholesterol(LDL-C)levels in both groups were lower than those before treatment,and the high density lipoprotein cholesterol(HDL-C)level was higher than that before treatment;in the combination group,the serum total cholesterol was(4.28±1.06)mmol/L,the triglyceride was(1.43±0.74)mmol/L and LDL-C was(2.68±0.75)mmol/L,which were lower than(4.81±0.95),(1.81±0.62)and(3.06±0.69)mmol/L in the control group;HDL-C of(1.48±0.39)mmol/L in the combination group was higher than(1.29±0.41)mmol/L in the control group(P<0.05).After treatment,the serum levels of tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in both groups were lower than those before treatment;the combination group had TNF-α of(26.65±3.04)ng/L,hs-CRP of(4.39±1.10)mg/L and IL-6 of(25.59±2.88)ng/L,which were lower than(31.19±3.36)ng/L,(5.32±1.06)mg/L and(33.37±3.59)ng/L in the control group(P<0.05).After treatment,the carotid intima-media thickness(IMT)and carotid plaque area decreased in both groups compared with those before treatment;the combination group had IMT of(1.09±0.22)mm and carotid plaque area of(0.09±0.02)mm2,which were lower than(1.21±0.16)mm and(0.16±0.03)mm2 in the control group(P<0.05).The incidence of cardiovascular events in the combination group was 2.33%,which was lower than 16.28% in the control group(P<0.05).Conclusion Aspirin combined with rosuvastatin has significant efficacy in the treatment of patients with<50% coronary artery stenosis,which can effectively improve the level of lipid metabolism in patients,reduce inflammation,and have a low incidence of cardiovascular events and high safety.
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