Analysis of the clinical effects of pulmonary surfactant therapy on severe neonatal respiratory distress syndrome
Objective To analyze the clinical effects of pulmonary surfactant therapy on severe neonatal respiratory distress syndrome.Methods 50 neonates with severe respiratory distress syndrome as the subjects.According to the random number table method,they were divided into a reference group and a discussion group,each with 25 cases.The reference group received conventional treatment,and the discussion group received pulmonary surfactant therapy.The blood gas analysis indicators,occurrence of adverse reactions,and treatment effect were compared between the two groups.Results After treatment,the blood pH of the discussion group was(7.36±0.38),the arterial oxygen partial pressure was(72.05±6.38)mm Hg(1 mm Hg=0.133 kPa)and the blood oxygen saturation was(96.83±1.71)%,which were higher than(7.19±0.18),(64.42±6.07)mm Hg and(90.63±1.63)% in the reference group;the discussion group had arterial carbon dioxide partial pressure of(40.28±2.53)mm Hg and inhaled oxygen concentration of(31.72±3.26)%,which were lower than(45.71±2.27)mm Hg and(40.63±3.58)% in the reference group(P<0.05).The incidence of adverse events in the discussion group was 8.00%,which was lower than 32.00% in the reference group(P<0.05).The total effective rate of 96.00% in the discussion group was significantly higher than 76.00% in the reference group(P<0.05).Conclusion Pulmonary surfactant therapy for severe neonatal respiratory distress syndrome can effectively improve blood gas analysis indicators,enhance treatment effect,and has a high safety,which plays an important role in improving the prognosis of children.
Severe neonatal respiratory distress syndromePulmonary surfactantClinical effect
万方数据
维普
