Observation on the curative effect of high-frequency oscillatory ventilation combined with sildenafil in persistent pulmonary hypertension of the newborn
Observation on the curative effect of high-frequency oscillatory ventilation combined with sildenafil in persistent pulmonary hypertension of the newborn
Objective To observe the curative effect of high-frequency oscillatory ventilation combined with sildenafil in persistent pulmonary hypertension of the newborn(PPHN).Methods A total of 83 newborns with PPHN were selected and randomly divided into a control group(42 cases,high-frequency oscillatory ventilation)and a combination group(41 cases,high-frequency oscillatory ventilation+sildenafil treatment).Both groups were compared in terms of clinical efficacy,systolic pulmonary artery pressure(SPAP),systemic systolic blood pressure(SBP),blood gas index[arterial oxygen saturation(SaO2),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)]before and after treatment,and incidence of adverse reactions during treatment.Results The total effective rate of 90.24% in the combination group was higher than 71.43% in the control group(P<0.05).After treatment,the systemic SBP of the control group was(67.54±6.82)mm Hg(1 mm Hg=0.133 kPa)and that of the combination group was(66.23±6.41)mm Hg;there was no significant difference in the systemic SBP between the two groups(P>0.05).After treatment,SPAP of(28.95±4.25)mm Hg in the combination group was lower than(37.59±4.36)mm Hg in the control group(P<0.05).After treatment,the combination group had SaO2 of(98.48±10.72)% and PaO2(89.69±9.59)mm Hg,which were higher than(91.39±10.23)% and(82.48±9.76)mm Hg in the control group;PaCO2 of(34.69±4.69)mm Hg in the combination group was lower than(48.46±5.21)mm Hg in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion High-frequency oscillatory ventilation combined with sildenafil is effective in the treatment of PPHN,which can reduce pulmonary artery pressure,improve respiratory function,and is worthy of clinical application.
关键词
新生儿/新生儿持续性肺动脉高压/高频振荡通气/西地那非
Key words
Newborn/Persistent pulmonary hypertension of the newborn/High-frequency oscillatory ventilation/Sildenafil
维普
万方数据