尿转铁蛋白、尿β2-微球蛋白联合尿微量白蛋白诊断早期糖尿病肾病的价值分析

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中文摘要：目的分析早期糖尿病肾病(DN)采用尿转铁蛋白(TRF)、尿β2-微球蛋白(β2-MG)联合尿微量白蛋白(UAlb)诊断的价值。方法回顾性分析 102 例 2 型糖尿病患者资料，根据诊断结果将其分为两组，其中 35 例早期DN患者为研究组，另 67 例单纯 2 型糖尿病患者为对照组。两组患者均接受尿TRF、尿β2-MG、UAlb检验。对比两组尿TRF、尿β2-MG、UAlb水平，对比尿TRF、尿β2-MG、UAlb单独检验与联合检验早期DN的诊断效能(敏感度、特异度、阴性预测值、阳性预测值、准确率)。结果与对照组[(1。20±0。75)、(0。12±0。08)、(15。02±3。00)mg/L]相比，研究组尿TRF、尿β2-MG、UAlb水平[(3。56±0。60)、(0。75±0。18)、(56。52±4。62)mg/L]更高(P<0。05)。尿TRF、尿β2-MG、UAlb联合检验早期DN阳性 36 例，尿TRF单独检验阳性 39 例，尿β2-MG单独检验阳性 38 例，UAlb单独检验阳性 37 例。尿TRF、尿β2-MG、UAlb联合检验对于早期DN的诊断敏感度 97。14%、特异度97。01%、阴性预测值 98。48%、阳性预测值 94。44%与准确率 97。06%均高于单独尿TRF检验的 71。43%、79。10%、84。13%、64。10%、76。47%，单独尿β2-MG检验的 77。14%、83。58%、87。50%、71。05%、81。37%，单独UAlb检验的 77。14%、85。07%、87。69%、72。97%、82。35%(P<0。05)。结论早期DN患者尿TRF、尿β2-MG、UAlb水平可见明显上升，联合检验的诊断价值更高。

外文标题：Analysis of the value of urinary transferrin and urinary β2-microglobulin combined with urinary microalbumin in the diagnosis of early diabetic nephropathy

外文摘要：Objective To analyze the value of urinary transferrin(TRF)and urinary β2-microglobulin(β2-MG)combined with urinary microalbumin(UAlb)in the diagnosis of early diabetic nephropathy(DN).Methods The data of 102 patients with type 2 diabetes were retrospectively analyzed,and they were divided into two groups according to the diagnosis results,including 35 patients with early DN as the study group and 67 patients with simple type 2 diabetes as the control group.Both groups were subjected to urinary TRF,urinary β2-MG,and UAlb tests.The levels of urinary TRF,urinary β2-MG,and UAlb were compared between the two groups,and the diagnostic efficacy(sensitivity,specificity,negative predictive value,positive predictive value,and accuracy)of the urinary TRF,urinary β2-MG,and UAlb tests alone and in combination for early DN.Results Compared with the control group[(1.20±0.75),(0.12±0.08)and(15.02±3.00)mg/L],the study group had higher levels of urinary TRF,urinary β2-MG and UAlb[(3.56±0.60),(0.75±0.18)and(56.52±4.62)mg/L](P<0.05).Urinary TRF,urinary β2-MG,and UAlb combined test showed 36 positive cases,urinary TRF test showed 39 positive cases,urinary β2-MG test showed 38 positive 38 cases,and UAlb test showed 37 positive cases.The diagnostic sensitivity of urinary TRF,urinary β2-MG and UAlb combined test for early DN was 97.14%,the specificity was 97.01%,the negative predictive value was 98.48%,the positive predictive value was 94.44%,and the accuracy was 97.06%,all of which were higher than 71.43%,79.10%,84.13%,64.10% and 76.47% of urinary TRF test,77.14%,83.58%,87.50%,71.05%,81.37% of urinary β2-MG test,and 77.14%,85.07%,87.69%,72.97%,82.35% of UAlb test(P<0.05).Conclusion The levels of urinary TRF,urinary β2-MG,and UAlb in patients with early DN can be seen to rise significantly,and the diagnostic value of the combined test is higher.

外文关键词：

Urinary transferrinUrinary β2-microglobulinUrinary microalbuminEarly diabetic nephropathy

作者：

张洁琳

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作者单位：

251600 商河县人民医院检验科

关键词：

尿转铁蛋白尿β2-微球蛋白尿微量白蛋白早期糖尿病肾病

出版年：

2024

DOI：