血清CA125、CEA与CA199检验在早期宫颈癌诊断中的应用研究

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维普

中文摘要：目的分析血清糖类抗原 125(CA125)、癌胚抗原(CEA)、糖类抗原 199(CA199)检验在早期宫颈癌诊断中的应用效果。方法选取 47 例早期宫颈癌患者作为观察组，另选取同期收治的 47 例宫颈良性疾病患者作为对照组，对其资料进行回顾性分析。两组患者均接受血清CA125、CEA、CA199检验。对比两组患者血清CA125、CEA、CA199 水平以及血清CA125、CEA、CA199 单独检验与联合检验对于早期宫颈癌的诊断效能。结果观察组患者CA125 为(40。55±7。65)U/ml，CEA为(8。20±1。85)ng/ml，CA199 为(38。56±7。70)U/ml;对照组患者CA125 为(20。56±5。89)U/ml，CEA为(3。02±1。50)ng/ml，CA199为(25。00±5。05)U/ml。与对照组相比，观察组血清CA125、CEA、CA199 水平更高(P<0。05)。血清CA125、CEA、CA199 联合检验早期宫颈癌的灵敏度 95。74%、特异度 93。62%、符合率 94。68%均高于单独CA125 检验的 72。34%、70。21%、71。28%，单独CEA检验的 76。60%、74。45%、75。53%，单独CA199检验的 76。60%、65。96%、71。28%(P<0。05)。结论血清CA125、CEA与CA199 在早期宫颈癌中的表达明显上升，联合检验能够提高诊断效能，为后续诊疗工作提供重要的参考依据。

外文标题：Application of serum CA125,CEA,and CA199 tests in the diagnosis of early cervical cancer

外文摘要：Objective To analyze the application effect of serum carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)tests in the diagnosis of early cervical cancer.Methods 47 patients with early cervical cancer were selected as the observation group,and another 47 patients with benign cervical diseases during the same period were selected as the control group.Both groups of patients underwent serum CA125,CEA,and CA199 tests.The levels of serum CA125,CEA,and CA199 were compared between the two groups,as well as the diagnostic efficacy of individual and combined tests for serum CA125,CEA,and CA199 in early cervical cancer.Results In the observation group,CA125 was(40.55±7.65)U/ml,CEA was(8.20±1.85)ng/ml,and CA199 was(38.56±7.70)U/ml;in the control group,CA125 was(20.56±5.89)U/ml,CEA was(3.02±1.50)ng/ml,and CA199 was(25.00±5.05)U/ml.Compared with the control group,the levels of serum CA125,CEA and CA199 in the observation group were higher(P<0.05).The sensitivity,specificity and conformity rate of the combined test of serum CA125,CEA,and CA199 for early cervical cancer were 95.74%,93.62% and 94.68%,all higher than 72.34%,70.21% and 71.28% of CA125 test,76.60%,74.45% and 75.53% of CEA test,and 76.60%,65.96% and 71.28% of CA199 test(P<0.05).Conclusion The expression of serum CA125,CEA,and CA199 is significantly increased in early cervical cancer.Combined testing can improve diagnostic efficacy and provide important reference for subsequent diagnosis and treatment work

外文关键词：

Carbohydrate antigen 125Carcinoembryonic antigenCarbohydrate antigen 199Early cervical cancer

作者：

梁才

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作者单位：

264200 威海市妇幼保健院检验科

关键词：

糖类抗原125 癌胚抗原糖类抗原199 早期宫颈癌

出版年：

2024

DOI：