Value analysis of peripheral blood neutrophil CD64 index in patients with bacterial infection
Objective To analyze the value of peripheral blood neutrophil CD64(nCD64)index in the diagnosis of bacterial infection.Methods 48 patients with bacterial infection were included in the bacterial infection group,and 60 healthy subjects were included in the healthy control group.Venous blood specimens were collected from the two groups,and nCD64 index and levels of procalcitonin(PCT),white blood cell count(WBC),C-reactive protein(CRP),and interleukin-6(IL-6)were measured.The nCD64 index and the levels of PCT,WBC,CRP,and IL-6 were compared between the bacterial infection group and the healthy control group,as well as between the poor prognosis group and the good prognosis group of patients with bacterial infections;the receiver operating characteristic(ROC)curves of the subjects were plotted to analyze the diagnostic efficiency of the nCD64 index and the levels of PCT,WBC,CRP,and IL-6 for bacterial infections.Results The bacterial infection group had nCD64 index of(4.57±0.47),PCT of(2.45±0.31)μg/L,WBC of(9.25±1.44)×109/L,CRP of(7.59±1.17)mg/L,and IL-6 of(10.37±1.13)pg/ml,which were significantly higher than(1.77±0.23),(0.35±0.09)μg/L,(7.30±1.41)×109/L,(6.56±1.25)mg/L,and(5.25±1.06)pg/ml in the healthy control group,and the difference was statistically significant(P<0.05).The poor prognosis group had nCD64 index of(5.39±0.50)and PCT of(2.77±0.38)μg/L,WBC of(10.07±1.23)×109/L,CRP of(8.45±1.04)mg/L,and IL-6 of(11.48±1.06)pg/ml,which were significantly higher than(3.54±0.52),(1.94±0.35)μg/L,(8.36±1.34)×109/L,(7.23±0.78)mg/L,and(9.26±1.02)pg/ml in the good prognosis group,and the difference was statistically significant(P<0.05).The nCD64 index had the highest sensitivity in the diagnosis of bacterial infections at 68.75% followed by PCT at 64.58%;PCT had the highest specificity in the diagnosis of bacterial infections at 93.33% followed by nCD64 index at 90.00% .Conclusion The diagnostic sensitivity of peripheral blood nCD64 index in bacterial infections is high,and the nCD64 index can change with the patient's condition,which is helpful for clinical differential diagnosis of bacterial infections and prognostic assessment.
万方数据
维普
