Comparison of effect of erythromycin combined with azithromycin sequential therapy and azithromycin alone in the treatment of mycoplasma pneumonia in children
Objective To compare the effect of erythromycin combined with azithromycin sequential therapy and azithromycin alone in the treatment of mycoplasma pneumonia in children.Methods A total of 68 children with mycoplasma pneumonia were randomly divided into a control group(34 cases,azithromycin alone)and a study group(34 cases,erythromycin combined with azithromycin sequential therapy)according to random numerical table.The total effective rate,remission time of clinical symptoms,length of hospital stay,level of inflammatory factors and pulmonary function index were compared between the two groups.Results The total effective rate of the study group(94.12% )was higher than that of the control group(73.53% )(χ2=5.314,P<0.05).In the study group,the remission time of fever was(1.52±0.43)d,the remission time of lung rale was(4.26±0.39)d,the remission time of cough was(3.74±0.43)d,the recovery time of white blood cell count was(5.35±0.46)d and the length of hospital stay was(6.07±0.61)d,which were shorter than(3.75±0.71),(7.04±0.64),(7.12±0.67),(7.62±0.55)and(8.11±0.57)d in the control group(t=15.665,21.629,24.756,18.460,14.248;P<0.05).Before treatment,the interleukin-6(IL-6),C-reactive protein(CRP)and procalcitonin(PCT)were not significantly different between the two groups(P>0.05).After treatment,the study group had IL-6 of(7.17±1.06)pg/ml,CRP of(3.22±0.42)mg/L,PCT of(0.29±0.08)ng/ml,which were lower than(10.51±1.13)pg/ml,(5.51±0.75)mg/L,(0.56±0.12)ng/ml in the control group(t=12.570,15.534,10.916;P<0.05).Before treatment,forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC were not significantly different between the two groups(P>0.05).After treatment,the study group had FEV1 of(2.08±0.45)L,FVC of(3.28±0.41)L,and FEV1/FVC of(75.34±4.02)%,which were higher than(1.71±0.29)L,(2.53±0.32)L,and(67.81±3.34)% in the control group(t=4.030,8.408,8.401;P<0.05).Conclusion Erythromycin combined with azithromycin sequential therapy in the treatment of children with mycoplasma pneumonia can improve the therapeutic effect,eliminate the inflammatory response,improve the lung function,and shorten the recovery time of children.
Mycoplasma pneumonia in childrenAzithromycinErythromycinLung functionInflammatory factors
万方数据
维普
