Analysis of the effect of different antimicrobial drug combinations on the anti-infective treatment and pathogen clearance of ICU patients with severe infections
Objective To analyze the effect of different antimicrobial drug combinations on intensive care unit(ICU)patients with severe infections.Methods 60 ICU patients with severe infections were divided into a single group and a combined group according to the treatment modality,each consisting of 30 patients.In the single group,patients were provided with a single antimicrobial drug treatment according to the results,while in the combined group,patients were treated with multiple antimicrobial drugs.Both groups were compared in terms of therapeutic effect,pathogen clearance rate,clinical time indexes(cough recovery time,drug onset time,mechanical ventilation time),immune function(CD3+,CD4+,CD8+,CD4+/CD8+),laboratory indicators[arterial partial pressure of oxygen(PO2),white blood cell count(WBC),and arterial partial pressure of carbon dioxide(PCO2)].Results In the combined group,the total effective rate was 93.33% and the pathogen clearance rate was 90.00%,which were higher than 70.00% and 63.33% in the single group,and the difference was significant(P<0.05).In the combined group,the cough recovery time was(4.85±1.10)d,the drug onset time was(14.11±0.14)d and the mechanical ventilation time was(2.86±0.14)d,which were all shorter than(6.69±1.05),(18.52±0.36)and(4.36±0.22)d in the single group.The difference was significant(P<0.05).After treatment,CD3+,CD4+,CD4+/CD8+in both groups were higher than those before treatment,and CD8+was lower than that before treatment;the combined group had CD3+of(65.14±3.58)%,CD4+of(41.63±2.05)% and CD4+/CD8+of(1.69±0.25),which were higher than(55.26±2.05)%,(34.78±3.05)% and(1.29±0.14)in the single group;CD8+of(23.47±2.14)% in the combined group was lower than(26.36±2.05)% in the single group;the difference was significant(P<0.05).After treatment,PO2 was higher and WBC and PCO2 were lower in both groups than those before treatment;PO2 of(11.58±1.36)kPa in the combined group was higher than(9.56±0.35)kPa in the single group;the combined group had WBC of(8.63±1.24)×109/L and PCO2 of(5.63±0.20)kPa,which were lower than(11.47±1.63)×109/L and(6.58±0.14)kPa in the single group;the difference was significant(P<0.05).Conclusion Combination therapy with multiple antimicrobial drugs is effective in treating ICU patients with severe infections,which can effectively remove pathogenic bacteria,shorten recovery time,as well as facilitate the improvement of patients'immune function and laboratory indicators.
Intensive care unitSevere infectionsDifferent antimicrobial drugPathogenAnti-infection
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