Analysis of the effect of Xingnaojing injection combined with acetylglutamide for injection on inflammatory response in patients with severe craniocerebral injury
Objective To study the effect of Xingnaojing injection combined with acetylglutamide for injection on inflammatory response in patients with severe craniocerebral injury.Methods 200 patients with severe traumatic brain injury were selected as the study subjects.The patients were randomly divided into an observation group and a control group,with 100 patients in each group.The control group received acetylglutamide for injection,while the observation group received Xingnaojing injection combined with acetylglutamide for injection.The therapeutic effect,National Institutes of Health Stroke Scale(NIHSS)score,incidence of adverse reactions and inflammatory indicators were compared between the two groups.Results There was no difference in NIHSS score between the observation group and the control group before treatment(P>0.05).After treatment,NIHSS score of(11.02±1.52)points in the observation group was different from(20.52±1.71)points in the control group(P<0.05).The total effective rate of 96.00%in the observation group was different from 79.00%in the control group(P<0.05).The incidence of adverse reactions of 3.00%in the observation group was lower than 10.00%in the control group(P<0.05).Before treatment,there was no difference in the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)between the two groups(P>0.05).After treatment,the levels of TNF-α,IL-6 and CRP in both groups were lower than those before treatment;the levels of TNF-α,IL-6 and CRP in the observation group were(22.11±1.66)ng/L,(9.17±1.24)pg/ml and(4.01±1.24)mg/L,which were lower than(24.16±1.02)ng/L,(15.99±1.04)pg/ml and(7.77±1.98)mg/L in the control group(P<0.05).Conclusion Combination therapy of Xingnaojing injection and acetylglutamide for injection for patients with severe traumatic brain injury has achieved significant therapeutic effects and can effectively alleviate the patient's inflammatory response.
Xingnaojing injectionAcetylglutamide for injectionSevere craniocerebral injury
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维普
