Effects of montmorillonite powder combined with Saccharomyces boulardii sachets on CRP levels in infants with acute diarrhea
Objective To explore the clinical effect of montmorillonite powder combined with Saccharomyces boulardii sachets on C-reactive protein(CRP)levels in infants with acute diarrhea and its influence on CRP level.Methods 62 infants with acute diarrhea were divided into a study group and a control group by double-blind lottery method,with 31 cases in each group.Both groups received basic symptomatic treatment.On this basis,the control group was treated with montmorillonite powder,and the study group was treated with montmorillonite powder combined with Saccharomyces boulardii sachets.The improvement time of clinical symptoms,levels of inflammatory factors,cellular immunological indexes,clinical effects and occurrence of adverse reactions were compared between the two groups.Results The improvement time of diarrhea,vomiting,abdominal pain and abnormal stool were(2.11±0.52),(1.19±0.38),(2.09±0.52)and(3.28±1.05)d in the study group,which were shorter than(4.09±0.97),(2.25±0.64),(3.96±0.87)and(5.74±1.73)d in the control group(P<0.05).After 6 d of treatment,CRP,interleukin-6(IL-6)and procalcitonin(PCT)in both groups were lower than those before treatment;the study group had CRP of(3.94±1.07)mg/L,IL-6 of(92.51±4.73)ng/L,and PCT of(1.19±0.42)μg/L,which were lower than(11.86±2.74)mg/L,(122.86±7.96)ng/L,and(1.85±0.61)μg/L in the control group(P<0.05).After 6 d of treatment,CD3+,CD4+and CD4+/CD8+in both groups were higher than those before treatment,and CD8+was lower than that before treatment;the study group had CD3+of(69.84±5.26)%,CD4+of(48.22±5.29)%,and CD4+/CD8+of(1.98±0.55),which were higher than(65.19±3.04)%,(43.15±2.79)%,and(1.42±0.26)in the control group;CD8+of(25.68±2.05)%in the study group was lower than(29.77±3.45)%in the control group(P<0.05).The total effective rate of the study group was 96.8%,which was higher than 77.4%of the control group(χ2=5.167,P=0.023<0.05).No intolerable serious adverse reactions occurred in both groups,and 2 cases(6.5%)of skin rash occurred in each group,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Montmorillonite powder combined with Saccharomycete boulardii sachets is effective and safe in the treatment of infants with acute diarrhea has rapid effect,and can reduce inflammation and improve immune function,which has the value of popularization and application.
Acute diarrhea in infantsMontmorillonite powderSaccharomyces boulardii sachetsInflammatory responseImmune function
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