The therapeutic effect of Xinbao Pill on sick sinus syndrome after atrial fibrillation ablation
Objective To observe the therapeutic effect of Xinbao Pill on sick sinus syndrome(SSS)after atrial fibrillation ablation.Methods According to the criteria of the randomized controlled trial,60 patients with sick sinus syndrome(sinus bradycardia,junctional escape rhythm,sinus arrest,etc.)after atrial fibrillation ablation were collected by double-blind method.After surgery,they were divided into a blank control group,a placebo group,and a Xinbao Pill intervention group based on different treatment plans,with 20 patients in each group.The blank control group was given conventional treatment,the placebo group was given placebo treatment on the basis of conventional treatment,and the Xinbao Pill intervention group was given Xinbao Pill treatment on the basis of conventional treatment.The clinical efficacy,adverse reactions,and clinical indicators after 1 and 6 months of intervention were compared among the three groups.Results The total effective rate of Xinbao Pill intervention group,placebo group and blank control group were 95.00%,70.00% and 70.00%,and the incidence of adverse reactions were 5.00%,10.00% and 10.00% .Comparison of the total effective rate of the three groups was statistically significant(P＜0.05);the total effective rate of Xinbao Pill intervention group was higher than that of placebo group and blank control group,and there was statistical significance(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).1 month after intervention,there were no significant differences in terms of average heart rate,slowest heart rate,fastest heart rate,24-h total heart rate change,sinus node recovery time(SNRT),corrected sinus node recovery time(CSNRT),sinoatrial conduction time(SACT),and quality of life score among the three groups(P＞0.05).6 months after intervention,comparison of the mean heart rate,slowest heart rate,fastest heart rate,24 h total heart rate change,SNRT,CSNRT,SACT and quality of life score of the three groups were statistically significant(P＜0.05);the average heart rate,slowest heart rate,fastest heart rate,24-h total heart rate change,SNRT,CSNRT,SACT,and quality of life of Xinbao Pill intervention group were better than those of blank control group and placebo group,and the difference was statistically significant(P＜0.05).Conclusion In the treatment of patients with sick sinus syndrome after atrial fibrillation ablation,oral administration of Xinbao Pill can significantly improve the treatment effect,improve the average heart rate,slowest heart rate,fastest heart rate,24-h total heart rate changes,SNRT,CSNRT,SACT changes and quality of life.The effect is ideal.
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