Analysis of the practical value of thromboelastography and routine coagulation test in chronic kidney disease
Objective To explore and analyze the practical value of thromboelastography and routine coagulation test in chronic kidney disease.Methods 135 patients with chronic kidney disease were selected.Based on the disease staging of the patients,they were divided into 5 groups:34 cases in stage Ⅰ-Ⅱ were classified as Group A,27 cases in stage Ⅲ were classified as Group B,15 cases in stage Ⅳ were classified as Group C,19 cases in stage Ⅴ without dialysis were classified as Group D,and 40 cases in stage V with dialysis were classified as Group E.All patients underwent routine coagulation tests and thromboelastography.Comparison was made on routine coagulation test indexes[prothrombinogen time(PT),thrombin time(TT),fibrinogen(FIB),D-dimer(DD),and internationalized normal ratio(INR)],and the thromboelastography indicators[coagulation index(CI),alpha angle(α),reaction time(R),clotting time(K),and maximum amplitude(Ma)]among the five groups,and their correlation with the severity of chronic kidney disease was analyzed.Results There were no statistical differences in the levels of PT,TT,FIB,DD and INR among five groups(P＞0.05).Group A had CI of(0.86±0.31),α of(74.89±1.89)°,R of(7.80±0.15)min,K of(1.80±0.11)min,and Ma of(55.91±1.99)mm;Group B had CI of(1.40±0.42),α of(72.55±1.16)°,R of(7.41±0.16)min,K of(1.40±0.16)min,and Ma of(60.51±2.01)mm;Group C had CI of(1.90±0.49),α of(70.61±1.01)°,R of(6.91±0.10)min,K of(1.20±0.12)min,and Ma of(63.30±2.21)mm;Group D had CI of(2.30±0.56),α of(68.30±0.79)°,R of(6.60±0.13)min,K of(1.11±0.09)min,Ma of(66.81±2.71)mm;Group E had CI of(2.89±0.71),α of(65.60±0.78)°,R of(6.20±0.11)min,K of(1.01±0.08)min,Ma of(71.30±2.82)mm.CI and Ma of Group A were lower than those of the other four groups,while α,R,and K were higher than those of the other four groups(P＜0.05);CI and Ma of Group B were lower than those of Group C and Group D,and Group E,while α,R,and K were higher than those in Group C,Group D,and Group E(P＜0.05);CI and Ma of Group C were lower than those in Group D and Group E,while α,R,and K were higher than those in Group D and Group E(P＜0.05);CI and Ma of Group D were lower than those in Group E,while α,R,and K were higher than those in Group E(P＜0.05).TT,PT,FIB,DD levels were negatively correlated with the severity of chronic kidney disease,while R,K,CI,Ma were positively correlated with the severity of chronic kidney disease(P＜0.05).Conclusion For the testing of chronic kidney disease,the sensitivity of thromboelastography test is higher than that of routine coagulation test.If the two are tested together,more accurate test results can be obtained,which has the value of promotion and application.
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