The role of oxytocin combined with ergometrine maleate on postpartum hemorrhage after vaginal delivery in high-risk parturients and its influence of coagulation factors
Objective To study the role of oxytocin combined with ergometrine maleate on postpartum hemorrhage after vaginal delivery in high-risk parturient and its influence of coagulation factors.Methods 60 high-risk parturients,all of whom underwent vaginal delivery.They were divided into a control group(32 cases)and an observation group(28 cases)according to admission order and maternal willingness.Patients in the control group were treated with oxytocin,and those in the observation group were treated with oxytocin combined with ergometrine maleate.Both groups were compared in terms of bleeding volume at 30 min,2 h,12 h,and 24 h postpartum,as well as the fundus height at 1 d,3 d,and 5 d postpartum,lochia,and adverse reactions,coagulation factors[activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB),thrombin time(TT)]before and after treatment.Results The postpartum bleeding volume in the observation group were(251.33±7.29),(298.25±12.38),(322.30±16.25)and(339.63±23.09)ml at 30 min,2 h,12 h,and 24 h postpartum,which were less than(282.56±10.23),(345.13±18.09),(386.31±20.32)and(426.52±29.57)ml in the control group(P＜0.05).The fundus height of the observation group were(15.92±2.55)and(13.72±2.31)cm at 3 and 5 d postpartum,which were lower than(18.13±2.23)and(15.63±2.52)cm of the control group(P＜0.05).After treatment,APTT,PT and TT in both groups were shorter than those before treatment,and FIB was higher than that before treatment;APTT,PT and TT in the observation group were shorter than those in the control group,and FIB was higher than that in the control group(P＜0.05).In the observation group,the duration of bloody lochia was(6.16±1.03)d and the time for complete disappearance of lochia was(5.46±0.75)weeks,which were shorter than(8.27±1.16)d and(6.33±1.02)weeks in the control group(P＜0.05).There was no statistical difference in the comparison of the total incidence of adverse reactions between the two groups(P＞0.05).The total effective rate of 96.43% in the observation group was higher than 78.13% in the control group(P＜0.05).Conclusion The use of oxytocin combined with ergometrine maleate after vaginal delivery has a significant preventive and therapeutic effect on postpartum hemorrhage.It can effectively improve coagulation factors,promote uterine involution,and improve lochia,with fewer adverse reactions.It is safe and reliable.
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