Correlation between body mass index and risk of breast cancer in women
Objective To explore the correlation between body mass index(BMI)and risk of breast cancer in women.Methods 120 female patients who underwent treatment for breast diseases were included in the study,of which 60 patients with breast cancer were selected as the study group and 60 patients with benign breast diseases as the control group.The basic information of the patients in the two groups was counted and compared,as well as the results of multivariate Logistic regression analysis of breast cancer risk in patients with different BMI(BMI＜18.5 kg/m2,18.5-24.0 kg/m2,24.1-28.0 kg/m2,and≥28 kg/m2 indicated underweight,normal,overweight,and obesity).The distribution of BMI in breast cancer patients with each molecular subtype(Luminal A type,Luminal B type,Human Epidermal Growth Factor Receptor-2(HER-2)-positive type,and triple-negative type).Results 46 patients(76.67% )were breastfed in the study group,and BMI was(23.99±3.11)kg/m2,which were different from 55 patients(91.67% )and(22.64±2.92)kg/m2 in the control group(P＜0.05).There were no differences in terms of age,menstrual status,age of menarche,age of first delivery,number of pregnancies,alcohol consumption,smoking,family history of breast cancer,and history of hormone drug use between the two groups(P＞0.05).Logistic regression analysis based on menstrual status showed that the risk of breast cancer increased with increasing BMI,especially in the postmenopausal female population(P＜0.05).Of the 60 breast cancer patients,24 cases were Luminal A type,21 cases were Luminal B type,9 cases were HER-2 positive type,and 6 cases were triple-negative type,among which hormone receptor-positive patients accounted for the highest at 75% .There were differences in BMI distribution among different molecular subtypes of breast cancer patients(P＜0.008).Among them,Luminal A type breast cancer patients had a higher proportion of overweight and obesity.There was a difference in the BMI distribution of Luminal A type compared with the other three subtypes(P＜0.008).Conclusion Weight gain leads to an increased risk of breast cancer,especially in postmenopausal women;and the risk of Luminal A type breast cancer is more strongly associated with weight gain.
Body mass indexBreast cancerMolecular subtypeMenopause
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